Abstract The phosphatidylinositol 3-kinase (PI3K)-Akt and the mammalian target of
rapamycin (mTOR) represent two vital intracellular signaling pathways, which are …

Objective Increased activity of PI3K/AKT/mTOR pathway has been observed in a huge
number of malignancies. This pathway can function as a prosurvival factor in leukemia stem …

Acute myeloid leukemia (AML) is the most common form of acute leukemia among adults
and accounts for the largest number of annual deaths due to leukemias in the United States …

Acute myeloid leukemia (AML) is the most common form of acute leukemia among adults
and accounts for the largest number of annual deaths due to leukemias in the United States …

Background Procedures to prevent severe graft-versus-host disease (GVHD) delay immune
reconstitution secondary to transplants of haploidentical haemopoietic stem cells for the …

Acute myeloid leukemia (AML) remains the most common form of acute leukemia among
adults and accounts for the largest number of annual deaths due to leukemias in the United …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) signaling axis plays a central role in cell proliferation, growth, and survival under …

Type I innate lymphoid cells (ILC1s) are critical regulators of inflammation and immunity in
mammalian tissues. However, their function in cancer is mostly undefined. Here, we show …

Abstract The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is crucial to many
aspects of cell growth, survival and apoptosis, and its constitutive activation has been …

Acute myeloid leukemia cells have constitutive activation of phosphatidylinositol 3 (PI3)
kinase and require PI3 kinase activation for survival; however, the function of the PI3 kinase …