[HTML][HTML] New opportunities and challenges of natural products research: When target identification meets single-cell multiomics

Y Zhu, Z Ouyang, H Du, M Wang, J Wang, H Sun… - … Pharmaceutica Sinica B, 2022 - Elsevier
Natural products, and especially the active ingredients found in traditional Chinese medicine
(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in …

[HTML][HTML] Marine natural products in clinical use

N Haque, S Parveen, T Tang, J Wei, Z Huang - Marine drugs, 2022 - mdpi.com
Marine natural products are potent and promising sources of drugs among other natural
products of plant, animal, and microbial origin. To date, 20 drugs from marine sources are in …

CMNPD: a comprehensive marine natural products database towards facilitating drug discovery from the ocean

C Lyu, T Chen, B Qiang, N Liu, H Wang… - Nucleic Acids …, 2021 - academic.oup.com
Marine organisms are expected to be an important source of inspiration for drug discovery
after terrestrial plants and microorganisms. Despite the remarkable progress in the field of …

Natural products as inspiration for the development of bacterial antibiofilm agents

RJ Melander, AK Basak, C Melander - Natural product reports, 2020 - pubs.rsc.org
Natural products have historically been a rich source of diverse chemical matter with
numerous biological activities, and have played an important role in drug discovery in many …

Accelerating drug discovery: synthesis of complex chemotypes via multicomponent reactions

MJ Buskes, A Coffin, DM Troast, R Stein… - ACS Medicinal …, 2023 - ACS Publications
The generation of multiple bonds in one reaction step has attracted massive interest in drug
discovery and development. Multicomponent reactions (MCRs) offer the advantage of …

[HTML][HTML] The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987–2020)

Y Hai, MY Wei, CY Wang, YC Gu, CL Shao - Marine Life Science & …, 2021 - Springer
Natural products derived from marine microorganisms have received great attention as a
potential resource of new compound entities for drug discovery. The unique marine …

Enriching cancer pharmacology with drugs of marine origin

PC Jimenez, DV Wilke, PC Branco… - British Journal of …, 2020 - Wiley Online Library
Marine natural products have proven, over the last half‐century, to be effective biological
modulators. These molecules have revealed new targets for cancer therapy as well as …

[HTML][HTML] Comprehensive virtual screening of the antiviral potentialities of marine polycyclic guanidine alkaloids against SARS-CoV-2 (COVID-19)

A El-Demerdash, AM Metwaly, A Hassan… - Biomolecules, 2021 - mdpi.com
The huge global expansion of the COVID-19 pandemic caused by the novel SARS-corona
virus-2 is an extraordinary public health emergency. The unavailability of specific treatment …

Marine natural products as source of new drugs: A patent review (2015–2018)

P Shinde, P Banerjee, A Mandhare - Expert opinion on therapeutic …, 2019 - Taylor & Francis
Introduction: Natural products from plants, animals, microbes, and minerals have long been
a traditional source for the treatment of human diseases. In the past decades, research on …

A propitious role of marine sourced polysaccharides: Drug delivery and biomedical applications

A Sharma, I Kaur, D Dheer, M Nagpal, P Kumar… - Carbohydrate …, 2023 - Elsevier
Numerous compounds, with extensive applications in biomedical and biotechnological
fields, are present in the oceans, which serve as a prime renewable source of natural …