[HTML][HTML] Solid lipid nanoparticles for drug delivery: pharmacological and biopharmaceutical aspects

S Scioli Montoto, G Muraca, ME Ruiz - Frontiers in molecular …, 2020 - frontiersin.org
In the golden age of pharmaceutical nanocarriers, we are witnessing a maturation stage of
the original concepts and ideas. There is no doubt that nanoformulations are extremely …

[HTML][HTML] Intestinal absorption study: Challenges and absorption enhancement strategies in improving oral drug delivery

M Azman, AH Sabri, QK Anjani, MF Mustaffa… - Pharmaceuticals, 2022 - mdpi.com
The oral route is the most common and practical means of drug administration, particularly
from a patient's perspective. However, the pharmacokinetic profile of oral drugs depends on …

An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers

Y Xu, N Shrestha, V Préat, A Beloqui - Advanced Drug Delivery Reviews, 2021 - Elsevier
Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …

[HTML][HTML] Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches

DJ Brayden, TA Hill, DP Fairlie, S Maher… - Advanced drug delivery …, 2020 - Elsevier
In its 33 years, ADDR has published regularly on the po5tential of oral delivery of biologics
especially peptides and proteins. In the intervening period, analysis of the preclinical and …

[HTML][HTML] Advances in oral peptide drug nanoparticles for diabetes mellitus treatment

Y Li, W Zhang, R Zhao, X Zhang - Bioactive Materials, 2022 - Elsevier
Peptide drugs play an important role in diabetes mellitus treatment. Oral administration of
peptide drugs is a promising strategy for diabetes mellitus because of its convenience and …

[HTML][HTML] Formulation strategies to improve the efficacy of intestinal permeation enhancers

S Maher, DJ Brayden - Advanced Drug Delivery Reviews, 2021 - Elsevier
The use of chemical permeation enhancers (PEs) is the most widely tested approach to
improve oral absorption of low permeability active agents, as represented by peptides …

Safety of surfactant excipients in oral drug formulations

S Maher, C Geoghegan, DJ Brayden - Advanced Drug Delivery Reviews, 2023 - Elsevier
Surfactants are a diverse group of compounds that share the capacity to adsorb at the
boundary between distinct phases of matter. They are used as pharmaceutical excipients …

Intestinal permeation enhancers to improve oral bioavailability of macromolecules: Reasons for low efficacy in humans

S Maher, C Geoghegan, DJ Brayden - Expert opinion on drug …, 2021 - Taylor & Francis
ABSTRACT Introduction Intestinal permeation enhancers (PEs) are substances that
transiently alter the intestinal epithelial barrier to facilitate permeation of macromolecules …

Oral delivery of biomacromolecules by overcoming biological barriers in the gastrointestinal tract: an update

S Liu, X Wen, X Zhang, S Mao - Expert opinion on drug delivery, 2023 - Taylor & Francis
Introduction Biomacromolecules have proven to be an attractive choice for treating diseases
due to their properties of strong specificity, high efficiency, and low toxicity. Besides greatly …

[HTML][HTML] Gastrointestinal permeation enhancers for the development of oral peptide pharmaceuticals

JC Kim, EJ Park, DH Na - Pharmaceuticals, 2022 - mdpi.com
Recently, two oral-administered peptide pharmaceuticals, semaglutide and octreotide, have
been developed and are considered as a breakthrough in peptide and protein drug delivery …