[HTML][HTML] Solid lipid nanoparticles for drug delivery: pharmacological and biopharmaceutical aspects
In the golden age of pharmaceutical nanocarriers, we are witnessing a maturation stage of
the original concepts and ideas. There is no doubt that nanoformulations are extremely …
the original concepts and ideas. There is no doubt that nanoformulations are extremely …
[HTML][HTML] Intestinal absorption study: Challenges and absorption enhancement strategies in improving oral drug delivery
M Azman, AH Sabri, QK Anjani, MF Mustaffa… - Pharmaceuticals, 2022 - mdpi.com
The oral route is the most common and practical means of drug administration, particularly
from a patient's perspective. However, the pharmacokinetic profile of oral drugs depends on …
from a patient's perspective. However, the pharmacokinetic profile of oral drugs depends on …
An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers
Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …
effectiveness, ease of administration, and high patient compliance. However, the absorption …
[HTML][HTML] Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches
In its 33 years, ADDR has published regularly on the po5tential of oral delivery of biologics
especially peptides and proteins. In the intervening period, analysis of the preclinical and …
especially peptides and proteins. In the intervening period, analysis of the preclinical and …
[HTML][HTML] Advances in oral peptide drug nanoparticles for diabetes mellitus treatment
Y Li, W Zhang, R Zhao, X Zhang - Bioactive Materials, 2022 - Elsevier
Peptide drugs play an important role in diabetes mellitus treatment. Oral administration of
peptide drugs is a promising strategy for diabetes mellitus because of its convenience and …
peptide drugs is a promising strategy for diabetes mellitus because of its convenience and …
[HTML][HTML] Formulation strategies to improve the efficacy of intestinal permeation enhancers
S Maher, DJ Brayden - Advanced Drug Delivery Reviews, 2021 - Elsevier
The use of chemical permeation enhancers (PEs) is the most widely tested approach to
improve oral absorption of low permeability active agents, as represented by peptides …
improve oral absorption of low permeability active agents, as represented by peptides …
Safety of surfactant excipients in oral drug formulations
S Maher, C Geoghegan, DJ Brayden - Advanced Drug Delivery Reviews, 2023 - Elsevier
Surfactants are a diverse group of compounds that share the capacity to adsorb at the
boundary between distinct phases of matter. They are used as pharmaceutical excipients …
boundary between distinct phases of matter. They are used as pharmaceutical excipients …
Intestinal permeation enhancers to improve oral bioavailability of macromolecules: Reasons for low efficacy in humans
S Maher, C Geoghegan, DJ Brayden - Expert opinion on drug …, 2021 - Taylor & Francis
ABSTRACT Introduction Intestinal permeation enhancers (PEs) are substances that
transiently alter the intestinal epithelial barrier to facilitate permeation of macromolecules …
transiently alter the intestinal epithelial barrier to facilitate permeation of macromolecules …
Oral delivery of biomacromolecules by overcoming biological barriers in the gastrointestinal tract: an update
S Liu, X Wen, X Zhang, S Mao - Expert opinion on drug delivery, 2023 - Taylor & Francis
Introduction Biomacromolecules have proven to be an attractive choice for treating diseases
due to their properties of strong specificity, high efficiency, and low toxicity. Besides greatly …
due to their properties of strong specificity, high efficiency, and low toxicity. Besides greatly …
[HTML][HTML] Gastrointestinal permeation enhancers for the development of oral peptide pharmaceuticals
JC Kim, EJ Park, DH Na - Pharmaceuticals, 2022 - mdpi.com
Recently, two oral-administered peptide pharmaceuticals, semaglutide and octreotide, have
been developed and are considered as a breakthrough in peptide and protein drug delivery …
been developed and are considered as a breakthrough in peptide and protein drug delivery …