With cardiovascular disease being the leading cause of morbidity and mortality worldwide,
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …

The heart requires fatty acids to maintain its activity. Various mechanisms regulate
myocardial fatty acid metabolism, such as energy production using fatty acids as fuel, for …

Background: The human heart primarily metabolizes fatty acids, and this decreases as
alternative fuel use rises in heart failure with reduced ejection fraction (HFrEF). Patients with …

Rationale: Lipid overload-induced heart dysfunction is characterized by cardiomyocyte
death, myocardial remodeling, and compromised contractility, but the impact of excessive …

Background: The failing heart is energy starved with impaired oxidation of long-chain fatty
acids (LCFAs) at the level of reduced CPT1 (carnitine palmitoyltransferase 1) activity at the …

Heart failure (HF) is a leading cause of mortality. Failing hearts undergo profound metabolic
changes, but a comprehensive evaluation in humans is lacking. We integrate plasma and …

Background Pathological cardiac hypertrophy is a major contributor of heart failure (HF),
which seriously threatens human's health world widely. Deregulation of m6A RNA …

Ceramide is a core molecule of sphingolipid metabolism that causes selective insulin
resistance and dyslipidemia. Research on its involvement in cardiovascular diseases has …

As a muscular pump that contracts incessantly throughout life, the heart must constantly
generate cellular energy to support contractile function and fuel ionic pumps to maintain …

Chronic kidney disease is associated with an increased risk for the development and
progression of cardiovascular disorders including hypertension, dyslipidemia, and coronary …