Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies

ME Burczynski, AJ Dorner - Pharmacogenomics, 2006 - Taylor & Francis
Peripheral blood represents an attractive tissue source in clinical pharmacogenomic studies,
given the feasibility of its collection from patients and its potential as a sentinel tissue to …

Analysis of whole genome biomarker expression in blood and brain

B Rollins, MV Martin, L Morgan… - American Journal of …, 2010 - Wiley Online Library
The consistency of peripheral gene expression data and the overlap with brain expression
has not been evaluated in biomarker discovery, nor has it been reported in multiple tissues …

The identification of gut neuroendocrine tumor disease by multiple synchronous transcript analysis in blood

IM Modlin, I Drozdov, M Kidd - PloS one, 2013 - journals.plos.org
Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are increasing in both
incidence and prevalence. A delay in correct diagnosis is common for these lesions. This …

Investigating gene expression profiles of whole blood and peripheral blood mononuclear cells using multiple collection and processing methods

A Gautam, D Donohue, A Hoke, SA Miller… - PLoS …, 2019 - journals.plos.org
Gene expression profiling using blood samples is a valuable tool for biomarker discovery in
clinical studies. Different whole blood RNA collection and processing methods are highly …

[HTML][HTML] Quality assurance of RNA expression profiling in clinical laboratories

W Tang, Z Hu, H Muallem, ML Gulley - The Journal of molecular diagnostics, 2012 - Elsevier
RNA expression profiles are increasingly used to diagnose and classify disease, based on
expression patterns of as many as several thousand RNAs. To ensure quality of expression …

Blood transcriptional signature of recombinant human erythropoietin administration and implications for antidoping strategies

J Durussel, DW Haile, K Mooses… - Physiological …, 2016 - journals.physiology.org
Recombinant human erythropoietin (rHuEPO) is frequently abused by athletes as a
performance-enhancing drug, despite being prohibited by the World Anti-Doping Agency …

Long-term storage of blood RNA collected in RNA stabilizing Tempus tubes in a large biobank–evaluation of RNA quality and stability

N Duale, WI Lipkin, T Briese, J Aarem… - BMC research …, 2014 - Springer
Background Establishing methods for secure long term storage of RNA is critical to realizing
the promise of biobanks in biomedical research. Here, we describe the results of yearly …

Comparison of blood RNA isolation methods from samples stabilized in Tempus tubes and stored at a large human biobank

J Aarem, G Brunborg, KK Aas, K Harbak… - BMC Research …, 2016 - Springer
Background More than 50,000 adult and cord blood samples were collected in Tempus
tubes and stored at the Norwegian Institute of Public Health Biobank for future use. In this …

Assessment of sample collection and storage methods for multicenter immunologic research in children

LA Matheson, TT Duong, AM Rosenberg… - Journal of …, 2008 - Elsevier
Multicenter studies involving both large and small centers separated by significant distances
pose unique challenges to biological sample collection. The objective of this study was to …

Genome-wide comparison of two RNA-stabilizing reagents for transcriptional profiling of peripheral blood

T Nikula, J Mykkänen, O Simell, R Lahesmaa - Translational Research, 2013 - Elsevier
Peripheral whole blood is relatively easily obtained for monitoring gene expression for
biomarker discovery using transcriptomic platforms such as genome-wide microarrays …