Disease modeling and target identification are the most crucial initial steps in drug
discovery, and influence the probability of success at every step of drug development …

The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …

Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …

In recent decades, mass spectrometry has moved more than ever before into the front line of
protein-centered research. After being established at the qualitative level, the more …

INTRODUCTION Cells have evolved quality control mechanisms that operate under normal
growth conditions and during stress to maintain protein homeostasis (proteostasis) and …

Proteomics researchers today face an interesting challenge: how to choose among the
dozens of data processing and analysis pipelines available for converting tandem mass …

Hydrogen isotopes are unique tools for identifying and understanding biological and
chemical processes. Hydrogen isotope labelling allows for the traceless and direct …

Many long non-coding RNAs (lncRNAs) affect gene expression, but the mechanisms by
which they act are still largely unknown. One of the best-studied lncRNAs is Xist, which is …

The turnover of endoplasmic reticulum (ER) ensures the correct biological activity of its
distinct domains. In mammalian cells, the ER is degraded via a selective autophagy pathway …

Great advances have been made in sensitivity and acquisition speed on the Orbitrap mass
analyzer, enabling increasingly deep proteome coverage. However, these advances have …