Regulatory T cells (Tregs) play a major role in establishing an immunosuppressive tumor
microenvironment. In order to fully uncover their role and molecular regulation in tumor …

Purpose Hepatocellular carcinoma (HCC) is a critical global health concern, with existing
treatments benefiting only a minority of patients. Recent findings implicate the chemokine …

Histiocytic sarcoma (HS) is an aggressive malignant neoplasm in dogs. Expression and
prognostic significance of transforming growth factor beta (TGF-β), programmed death …

To chart cell composition and cell state changes that occur during the transformation of
healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated …

MicroRNAs (miRNAs), or small non-coding RNAs, modulate the expression of mRNAs and,
consequently, a variety of signal transduction pathways. Due to their dysregulation in …

Background The correlation of the expression of ankyrin repeat domain (ANKRD) family
members with renal cell carcinoma prognosis was investigated. Methods The GEPIA2 …

Tumor-intrinsic signaling pathways can drastically affect the tumor immune
microenvironment (TME), promoting tumor progression and resistance to immunotherapy by …

Simple Summary Multiple myeloma remains an essentially incurable blood cancer. New
patients with multiple myeloma are often treated with induction chemotherapy, stem cell …

Simple Summary ScRNA-seq is a powerful tool for investigating the cancer
microenvironment, but the cost of analysing every scientific scenario is prohibitive …

目前针对肿瘤的治疗方法不断进步, 免疫治疗已成为遏制肿瘤进展的有效手段.
但目前的免疫治疗仍有局限性, 只有较少的一部分特定患者可以从免疫治疗中完全获益 …