Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …

Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells
undergoing a defective differentiation due to genomic and epigenetic impairments …

Neuroblastoma is a pediatric tumor of the developing sympathetic nervous system.
However, the cellular origin of neuroblastoma has yet to be defined. Here we studied the …

Abstract Characterization of the progression of cellular states during human embryogenesis
can provide insights into the origin of pediatric diseases. We examined the transcriptional …

Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …

Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …

The cell ecology and spatial niche implicated in the dynamic and sequential process of lung
adenocarcinoma (LUAD) from adenocarcinoma in situ (AIS) to minimally invasive …

Immunotherapy with anti-GD2 antibodies has advanced the treatment of children with high-
risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms …

Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood
tumor has been molecularly defined at the primary cancer site, however, the bone marrow …

Peritoneal metastasis is the leading cause of death for gastrointestinal cancers. The native
and therapy-induced ascites ecosystems are not fully understood. Here, we characterize …