Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …

Abstract Purpose of Review The evolving information of the initiation, tumor cell
heterogeneity, and plasticity of childhood neuroblastoma has opened up new perspectives …

Rhabdomyosarcoma (RMS) is a group of pediatric cancers with features of developing
skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest …

Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin
lymphoma distinguished by the presence of clonal malignant T cells. The heterogeneity of …

Transcription factors (TFs) can define distinct cellular identities despite nearly identical DNA-
binding specificities. One mechanism for achieving regulatory specificity is DNA-guided TF …

Understanding the complete immune cell composition of human neuroblastoma (NB) is
crucial for the development of immunotherapeutics. Here, we perform single-cell RNA …

Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one
of the most important prognostic factors, with children less than 1 year old having favorable …

Cancer has become one of the greatest threats to human health, and new technologies are
urgently needed to further clarify the mechanisms of cancer so that better detection and …

Neuroblastoma is the most common extracranial solid tumor and accounts for∼ 10% of
pediatric cancer-related deaths. The exact cell of origin has yet to be elucidated, but it is …

Neuroblastoma is a solid, neuroendocrine tumor with divergent clinical behavior ranging
from asymptomatic to fatal. The diverse clinical presentations of neuroblastoma are directly …