The Neuroblastoma Microenvironment, Heterogeneity and Immunotherapeutic Approaches
PA Polychronopoulos, OC Bedoya-Reina, JI Johnsen - Cancers, 2024 - mdpi.com
Simple Summary Neuroblastoma, a cancer of the peripheral nervous system, is the most
common and deadly tumor that occurs in childhood. In order to cure more patients with …
common and deadly tumor that occurs in childhood. In order to cure more patients with …
Dissecting tumor transcriptional heterogeneity from single-cell RNA-seq data by generalized binary covariance decomposition
Profiling tumors with single-cell RNA sequencing (scRNA-seq) has the potential to identify
recurrent patterns of transcription variation related to cancer progression, and produce new …
recurrent patterns of transcription variation related to cancer progression, and produce new …
[HTML][HTML] Arsenic trioxide induces the differentiation of retinoic acid-resistant neuroblastoma cells via upregulation of HoxC9
C Li, C Feng, Y Chen, P Wu, P Li… - … in Clinical and …, 2022 - advances.umw.edu.pl
Background. Neuroblastoma (NB) is one of the most common extracranial tumors with
limited therapeutic options. Retinoic acid (RA) has been identified to play anticancer role …
limited therapeutic options. Retinoic acid (RA) has been identified to play anticancer role …
[HTML][HTML] Single-cell transcriptome sequencing reveals tumor heterogeneity in family neuroblastoma
Y Zhang, Y Ma, Q Liu, Y Du, L Peng, J Zhou… - Frontiers in …, 2023 - frontiersin.org
Neuroblastoma (NB) is the most common extracranial solid tumor in childhood, and it is now
believed that some patients with NB have an underlying genetic susceptibility, which may be …
believed that some patients with NB have an underlying genetic susceptibility, which may be …
[HTML][HTML] DeepDecon accurately estimates cancer cell fractions in bulk RNA-seq data
J Huang, Y Du, A Stucky, KR Kelly, JF Zhong, F Sun - Patterns, 2024 - cell.com
Understanding the cellular composition of a disease-related tissue is important in disease
diagnosis, prognosis, and downstream treatment. Recent advances in single-cell RNA …
diagnosis, prognosis, and downstream treatment. Recent advances in single-cell RNA …
[HTML][HTML] Mitotic Dysregulation at Tumor Initiation Creates a Therapeutic Vulnerability to Combination Anti-Mitotic and Pro-Apoptotic Agents for MYCN-Driven …
L Zhai, A Balachandran, R Larkin… - International Journal of …, 2023 - mdpi.com
MYCN amplification occurs in approximately 20–30% of neuroblastoma patients and
correlates with poor prognosis. The TH-MYCN transgenic mouse model mimics the …
correlates with poor prognosis. The TH-MYCN transgenic mouse model mimics the …
The expression of PHOX2B in bone marrow and peripheral blood predicts adverse clinical outcome in non-high-risk neuroblastoma
H Fan, T Xing, H Hong, C Duan, W Zhao… - Pediatric Hematology …, 2022 - Taylor & Francis
Paired-like homeobox 2B (PHOX2B) is a highly sensitive and specific biomarker for
diagnosing neuroblastoma, as well as detecting minimal residual disease in neuroblastoma …
diagnosing neuroblastoma, as well as detecting minimal residual disease in neuroblastoma …
[HTML][HTML] Cell communication pathway prognostic model identified detrimental neurodevelopmental pathways in neuroblastoma
J Wang, H Li, Y Xue, Y Zhang, X Ma, C Zhou, L Rong… - Neoplasia, 2024 - Elsevier
Neurodevelopmental cell communication plays a crucial role in neuroblastoma prognosis.
However, determining the impact of these communication pathways on prognosis is …
However, determining the impact of these communication pathways on prognosis is …
Response to Kildsiute et al. and Bedoya-Reina and Schlisio
R Yang, W Luo, Y Zhan, K Li, J Wang, R Dong - Cancer Cell, 2021 - cell.com
We appreciate Kildsiute et al. and Bedoya-Reina and Schlisio for their attention to our work
and comments on our publication (Dong et al., 2020). We believe their letters and our …
and comments on our publication (Dong et al., 2020). We believe their letters and our …
Integration of clinical characteristics and molecular signatures of the tumor microenvironment to predict the prognosis of neuroblastoma
H Cheng, L Zhang, S Yang, Q Ren, S Chang… - Journal of Molecular …, 2023 - Springer
This study aimed to analyze the clinical characteristics, cell types, and molecular
characteristics of the tumor microenvironment to better predict the prognosis of …
characteristics of the tumor microenvironment to better predict the prognosis of …