Mitochondria are key decoding stations of the apoptotic process. In support of this view, a
large body of experimental evidence has unambiguously revealed that, in addition to the …

Human pathologies such as vascular malformations, hemorrhagic stroke, and edema have
been associated with defects in the organization of endothelial cell junctions. Understanding …

BACKGROUND: Monocyte Chemoattractant Protein (MCP)-1, a potent monocyte attractant,
is a member of the CC chemokine subfamily. MCP-1 exerts its effects through binding to G …

Background Juvenile polyposis and hereditary haemorrhagic telangiectasia are autosomal
dominant disorders with distinct and non-overlapping clinical features. The former, an …

ALK1 is an endothelial-specific type I receptor of the TGFβ receptor family whose
heterozygous mutations cause hereditary hemorrhagic telangiectasia type 2. Although …

Angiogenesis is a complex process, requiring a finely tuned balance between numerous
stimulatory and inhibitory signals. ALK1 (activin receptor like-kinase 1) is an endothelial …

Angiogenesis—the growth of new blood vessels—is a crucial force for shaping the nervous
system and protecting it from disease. Recent advances have improved our understanding …

Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant disorder
characterised by epistaxis, telangiectases, and multiorgan vascular dysplasia. The two …

A multifunctional microRNA, miR-155, has been recently recognized as an important
modulator of numerous biological processes. In our previous in vitro studies, miR-155 was …

Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central
nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and …