c-MET as a potential therapeutic target and biomarker in cancer
The receptor tyrosine kinase c-MET and its ligand, hepatocyte growth factor (HGF), regulate
multiple cellular processes that stimulate cell proliferation, invasion and angiogenesis. This …
multiple cellular processes that stimulate cell proliferation, invasion and angiogenesis. This …
Magnetically enhanced nucleic acid delivery. Ten years of magnetofection—Progress and prospects
C Plank, O Zelphati, O Mykhaylyk - Advanced drug delivery reviews, 2011 - Elsevier
Nucleic acids carry the building plans of living systems. As such, they can be exploited to
make cells produce a desired protein, or to shut down the expression of endogenous genes …
make cells produce a desired protein, or to shut down the expression of endogenous genes …
The semaphorins
U Yazdani, JR Terman - Genome biology, 2006 - Springer
Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-
rich semaphorin protein domains, that have important roles in a variety of tissues. Humans …
rich semaphorin protein domains, that have important roles in a variety of tissues. Humans …
Targeting the hepatocyte growth factor–cMET axis in cancer therapy
GR Blumenschein Jr, GB Mills… - Journal of clinical …, 2012 - ascopubs.org
The hepatocyte growth factor (HGF) and its receptor, the transmembrane tyrosine kinase
cMET, promote cell proliferation, survival, motility, and invasion as well as morphogenic …
cMET, promote cell proliferation, survival, motility, and invasion as well as morphogenic …
MET oncogene in non-small cell lung cancer: mechanism of MET dysregulation and agents targeting the HGF/c-Met axis
H Liang, M Wang - OncoTargets and therapy, 2020 - Taylor & Francis
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide
and has a poor prognosis. Current treatments for advanced NSCLC included traditional …
and has a poor prognosis. Current treatments for advanced NSCLC included traditional …
ICAM-1-mediated, Src-and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration
MJ Allingham, JD van Buul… - The Journal of Immunology, 2007 - journals.aai.org
Leukocyte transendothelial migration (TEM) has been modeled as a multistep process
beginning with rolling adhesion, followed by firm adhesion, and ending with either …
beginning with rolling adhesion, followed by firm adhesion, and ending with either …
Semaphorins in health and disease
D Fard, L Tamagnone - Cytokine & growth factor reviews, 2021 - Elsevier
Cell-cell communication is pivotal to guide embryo development, as well as to maintain adult
tissues homeostasis and control immune response. Among extracellular factors responsible …
tissues homeostasis and control immune response. Among extracellular factors responsible …
Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages
Increased evidence suggests that cancer-associated inflammation supports tumor growth
and progression. We have previously shown that semaphorin 4D (Sema4D), a ligand …
and progression. We have previously shown that semaphorin 4D (Sema4D), a ligand …
Mechanisms of endothelial cell migration
UR Michaelis - Cellular and molecular life sciences, 2014 - Springer
Cell migration plays a central role in a variety of physiological and pathological processes
during our whole life. Cellular movement is a complex, tightly regulated multistep process …
during our whole life. Cellular movement is a complex, tightly regulated multistep process …
Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions
Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …