Numerous cell surface receptors, including tyrosine kinase and G protein‐coupled
receptors, play critical roles in endothelial cell function and blood vessel development …

Tumor progression and metastasis depend on the ability of cancer cells to initiate
angiogenesis and ensure delivery of oxygen, nutrients, and growth factors to rapidly dividing …

Semaphorins are a large family of secreted and membrane-bound molecules that were
initially implicated in the development of the nervous system and in axon guidance. More …

The semaphorins were initially characterized as axon guidance factors, but have
subsequently been implicated also in the regulation of immune responses, angiogenesis …

Semaphorin 4D (sema4D; CD100) is an integral membrane protein and the ligand for two
receptors, CD72 and plexin-B1. Soluble sema4D has been shown to evoke angiogenic …

Purpose: Squamous cell carcinoma of the head and neck (HNSCC), the sixth most prevalent
cancer among men worldwide, is associated with poor prognosis, which has improved only …

The semaphorins are a family of proteins originally identified as regulators of axon growth
that recently have been implicated in blood vessel development. The plexins are high affinity …

Originally identified as axon guidance molecules, semaphorins are now known to be widely
expressed mediators that play significant roles in immune responses and organ …

The development of head and neck squamous cell carcinoma (HNSCC) involves the
accumulation of genetic and epigenetic alterations in tumor-suppressor proteins, together …

Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by immune
cell infiltration of CNS, blood–brain barrier (BBB) breakdown, localized myelin destruction …