Intercellular communication within the bone microenvironment is critical for the maintenance
of normal bone structure. Osteoblast-lineage cells at all stages of differentiation, from …

Semaphorins are regulatory molecules that are linked to the modulation of several cancer
processes, such as angiogenesis, cancer cell invasiveness and metastasis, tumor growth …

The Wilms' tumor suppressor 1 (WT1) gene encodes a DNA-and RNA-binding protein that
plays an essential role in nephron progenitor differentiation during renal development. To …

Sema4D-induced activation of plexin-B1 has been reported to evoke different and
sometimes opposing cellular responses. The mechanisms underlying the versatility of plexin …

Hepatocyte growth factor (HGF) is the ligand for the tyrosine kinase receptor c-Met
(Mesenchymal Epithelial Transition Factor also known as Hepatocyte Growth Factor …

The hallmarks of cancer include multiple alterations in the physiological processes occurring
in normal tissues, such as cell proliferation, apoptosis, and restricted cell migration. These …

Sema4D, also known as CD100, is a protein belonging to class IV semaphorin. Its
physiologic roles in the immune and nervous systems have been extensively explored …

The semaphorins were initially described as axon guidance factors, but have recently been
implicated in a variety of physiological and developmental functions, including regulation of …

Semaphorins were originally identified as axon guidance cues in the development of the
nervous system. In recent years, numerous studies have determined that they are also …

Class 3 semaphorins (sema 3) are secreted guidance proteins. Sema 3A expressed by
endothelial cells controls vascular morphogenesis through integrin inhibition. Sema 3C is …