We have recently shown that Semaphorin 4B (SEMA4B) inhibits the invasion of non-small
cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. In the …

The axon guidance cues semaphorins (Semas) and their receptors plexins have been
shown to regulate both physiological and pathological angiogenesis. Sema4A plays an …

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor, for which the
development of new biomarkers and therapeutic targets has become critical. The main …

Prostate cancer (PCa) is among the most commonly-occurring cancers worldwide and a
leader in cancer-related deaths. Local non-invasive PCa is highly treatable but limited …

The semaphorins were initially characterized as repulsive axon guidance factors. However,
they are currently also recognized as important regulators of diverse biological processes …

Background Plexins are a large family of transmembrane receptors for the Semaphorins,
known for their role in the assembly of neural circuitry. More recently, Plexins have been …

Tumor progression and metastasis depend on the ability of cancer cells to initiate
angiogenesis to ensure delivery of oxygen, nutrients, and growth factors to tumor cells and …

CCR5-triggered chemotaxis in primary human macrophages depends on both Giα-
dependent pathways and a novel Giα-independent mechanism. MIP-1β/CCL4 is a principal …

At present, a large number of studies have demonstrated that c-Met generally exerts a
crucial function of promoting tumor cells proliferation and differentiation in digestive system …

Semaphorins constitute a large family of membrane-bound and secreted proteins that
provide guidance cues for axon pathfinding and cell migration. Although initially discovered …