Purpose: To characterize the involvement of Semaphorin 7A (Sema7a) in corneal
neovascularization (NV). Methods: We generated anti-Sema7A antibodies to detect protein …

Semaphorins belong to a large family of proteins well-conserved along evolution from
viruses to mammalians. Secreted and membrane-bound semaphorins participate in a wide …

Background Semaphorin 4D (Sema4D) belongs to the class IV semaphorins, and
accumulating evidence has indicated that its elevated level may be one strategy by which …

Background The retina has a unique three-dimensional architecture, the precise
organization of which allows for complete sampling of the visual field. Along the radial or …

Abstract Background objectives Semaphorin 4D (Sema4D) and its receptor, Plexin-B1, are
involved in the pathogenesis of squamous cell carcinoma (SCC) by mediating angiogenesis …

Semaphorins and their receptors, plexins, carry out important functions during development
and disease. In contrast to the well-characterized plexin A family, however, very little is …

Head and neck squamous cell carcinomas (HNSCCs) frequently invade the bones of the
facial skeleton. Semaphorin 4D (Sema4D) is an axon guidance molecule produced by …

Abstract Semaphorin 4D (Sema4D) is a classic member of the semaphorin family involved in
axonal guidance processes. The key effects of Sema4D in neurons are mediated by high …

Neovascularization occurring in atherosclerotic plaque leads to acceleration of plaque
growth through increased leukocyte infiltration and reactive oxygen species (ROS) …

In breast cancer, nerve presence has been correlated with more invasive disease and worse
prognosis, yet the mechanisms by which different types of peripheral nerves drive tumor …