Semaphorins were originally discovered as essential mediators involved in regulation of
axonal growth during development of the nervous system. Ubiquitously expressed on …

Melanoma arises through complex genetic and epigenetic changes, resulting in
uncontrolled proliferation, invasion, and metastatic disease. Semaphorins regulate axon …

Idiopathic hypogonadotropic hypogonadism (IHH) comprises a group of rare genetic
disorders characterized by pubertal failure caused by gonadotropin‐releasing hormone …

Cardiovascular disease remains the leading cause of death and morbidity worldwide.
Inflammatory responses after percutaneous coronary intervention led to neoathrosclerosis …

The imbalance between bone‐resorbing osteoclasts and bone‐forming osteoblasts often
leads to bone destructive diseases such as osteoporosis. In contrast to the development of …

The semaphorin 4D (Sema4D) receptor plexin-B1 constitutively interacts with particular Rho
guanine nucleotide exchange factors (RhoGEFs) and thereby mediates Sema4D-induced …

Background Dairy cows can readily overconsume dietary energy during most of the
prepartum period, often leading to higher prepartal concentrations of insulin and glucose …

Background: Plex-B1, the receptor of Sema4D, has been implicated in tumour growth,
angiogenesis and metastasis. The binding of Sema4D to Plex-B1 can trigger the activation …

Solid tumors not only comprise malignant cells but also other nonmalignant cell types,
forming a unique microenvironment that can strongly influence the behavior of tumor cells …

Small vessel diseases, such as ischemic retinopathy and cerebral small vessel disease
(CSVD), are increasingly recognized in patients with diabetes, dementia and …