A survey of current trends in computational drug repositioning

J Li, S Zheng, B Chen, AJ Butte… - Briefings in …, 2016 - academic.oup.com
Computational drug repositioning or repurposing is a promising and efficient tool for
discovering new uses from existing drugs and holds the great potential for precision …

[HTML][HTML] A review of computational drug repurposing

K Park - Translational and clinical pharmacology, 2019 - ncbi.nlm.nih.gov
Although sciences and technology have progressed rapidly, de novo drug development has
been a costly and time-consuming process over the past decades. In view of these …

A review of network-based approaches to drug repositioning

M Lotfi Shahreza, N Ghadiri, SR Mousavi… - Briefings in …, 2018 - academic.oup.com
Experimental drug development is time-consuming, expensive and limited to a relatively
small number of targets. However, recent studies show that repositioning of existing drugs …

[HTML][HTML] Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer

P Nowak-Sliwinska, L Scapozza, AR i Altaba - Biochimica et Biophysica …, 2019 - Elsevier
The strategy of using existing drugs originally developed for one disease to treat other
indications has found success across medical fields. Such drug repurposing promises faster …

A bibliometric review of drug repurposing

NC Baker, S Ekins, AJ Williams, A Tropsha - Drug discovery today, 2018 - Elsevier
Highlights•A bibliometric review of drug repurposing provides novel insights into the
practice.•Some drugs have been tried in hundreds of diseases.•Even an old drug like …

Broad-coverage biomedical relation extraction with SemRep

H Kilicoglu, G Rosemblat, M Fiszman, D Shin - BMC bioinformatics, 2020 - Springer
Background In the era of information overload, natural language processing (NLP)
techniques are increasingly needed to support advanced biomedical information …

Machine learning applications in drug development

C Réda, E Kaufmann, A Delahaye-Duriez - Computational and structural …, 2020 - Elsevier
Due to the huge amount of biological and medical data available today, along with well-
established machine learning algorithms, the design of largely automated drug development …

Drug repositioning: new approaches and future prospects for life-debilitating diseases and the COVID-19 pandemic outbreak

ZY Low, IA Farouk, SK Lal - Viruses, 2020 - mdpi.com
Traditionally, drug discovery utilises a de novo design approach, which requires high cost
and many years of drug development before it reaches the market. Novel drug development …

Recent advances in biomedical literature mining

S Zhao, C Su, Z Lu, F Wang - Briefings in Bioinformatics, 2021 - academic.oup.com
The recent years have witnessed a rapid increase in the number of scientific articles in
biomedical domain. These literature are mostly available and readily accessible in …

Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality

H Xu, MC Aldrich, Q Chen, H Liu… - Journal of the …, 2015 - academic.oup.com
Objectives Drug repurposing, which finds new indications for existing drugs, has received
great attention recently. The goal of our work is to assess the feasibility of using electronic …