Toxicity testing in the 21st century: progress in the past decade and future perspectives
D Krewski, ME Andersen, MG Tyshenko… - Archives of …, 2020 - Springer
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …
based on expanded application of high-throughput in vitro screening and in silico methods …
Advanced tools for the safety assessment of nanomaterials
Engineered nanomaterials (ENMs) have tremendous potential to produce beneficial
technological impact in numerous sectors in society. Safety assessment is, of course, of …
technological impact in numerous sectors in society. Safety assessment is, of course, of …
Adverse outcome pathways: opportunities, limitations and open questions
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …
formalized, transparent and quality-controlled way, mechanistic information to apical …
[HTML][HTML] New approach methodologies in human regulatory toxicology–Not if, but how and when!
S Schmeisser, A Miccoli, M von Bergen… - Environment …, 2023 - Elsevier
The predominantly animal-centric approach of chemical safety assessment has increasingly
come under pressure. Society is questioning overall performance, sustainability, continued …
come under pressure. Society is questioning overall performance, sustainability, continued …
Physiological‐based pharmacokinetic modeling trends in pharmaceutical drug development over the last 20‐years; in‐depth analysis of applications, organizations …
E El‐Khateeb, S Burkhill, S Murby… - … & Drug Disposition, 2021 - Wiley Online Library
We assess the advancement of physiologically based pharmacokinetic (PBPK) modeling
and simulation (M&S) over the last 20 years (start of 2000 to end of 2019) focusing on the …
and simulation (M&S) over the last 20 years (start of 2000 to end of 2019) focusing on the …
[HTML][HTML] Recommendation on test readiness criteria for new approach methods (NAM) in toxicology: exemplified for developmental neurotoxicity (DNT)
A Bal-Price, HT Hogberg, KM Crofton, M Daneshian… - Altex, 2018 - ncbi.nlm.nih.gov
Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …
such new approach methods (NAMs) in a regulatory context, criteria to define their …
Advancing computational toxicology by interpretable machine learning
Chemical toxicity evaluations for drugs, consumer products, and environmental chemicals
have a critical impact on human health. Traditional animal models to evaluate chemical …
have a critical impact on human health. Traditional animal models to evaluate chemical …
[HTML][HTML] Human in vitro models of nonalcoholic fatty liver disease
Abstract Systems-oriented approaches involving integrated in vitro and in silico models are
emerging as a basis for future risk assessment strategies to address the current challenge in …
emerging as a basis for future risk assessment strategies to address the current challenge in …
Development and analysis of an adverse outcome pathway network for human neurotoxicity
N Spinu, A Bal-Price, MTD Cronin, SJ Enoch… - Archives of …, 2019 - Springer
An adverse outcome pathway (AOP) network is an attempt to represent the complexity of
systems toxicology. This study illustrates how an AOP network can be derived and analysed …
systems toxicology. This study illustrates how an AOP network can be derived and analysed …
New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk …
For almost fifteen years, the availability and regulatory acceptance of new approach
methodologies (NAMs) to assess the absorption, distribution, metabolism and excretion …
methodologies (NAMs) to assess the absorption, distribution, metabolism and excretion …