Systems toxicology approach explores target-pathway relationship and adverse health impacts of ubiquitous environmental pollutant bisphenol A

M Nagarajan, GB Maadurshni… - Journal of Toxicology …, 2022 - Taylor & Francis
The effects of environmental chemicals on health outcomes may be underestimated due to
deficiency of knowledge regarding the actions of compounds on toxico-pathogenic …

System-wide health risk prediction for 4-methyl-2, 4-bis (4-hydroxyphenyl) pent-1-ene (MBP), a major active metabolite of environmental pollutant and food …

GB Maadurshni, M Nagarajan, S Priyadharshini… - Toxicology, 2023 - Elsevier
Human exposure to plastic contaminated foods and environmental micro/nano plastic
derived chemicals necessitates system-wide health risk assessment. Hence, current study …

[图书][B] Modelling of quantitative Adverse Outcome Pathways

N Spînu - 2021 - search.proquest.com
With the growth of green chemistry initiatives, there is a demand for improved regulatory
assessment of human exposure to exogenous factors. Proposed a decade ago, the adverse …

Transcriptional analyses of acute per os exposure and co-exposure of 4-vinylcyclohexene and methylmercury-contaminated diet in adults of Drosophila melanogaster

BC Piccoli, ALA Segatto, ELS Loreto, JCF Moreira… - Environmental …, 2020 - Elsevier
Continuous exposure to low levels of toxic substances can be associated with delayed
physical disturbances, which can be preceded by changes in enzyme activities and gene …

Shotgun Lipidomics of Rodent Tissues

O Lavrynenko, S Dijon, B Titz, NV Ivanov - JoVE (Journal of Visualized …, 2022 - jove.com
Lipids play a vital role as essential components of all prokaryotic and eukaryotic cells.
Constant technological improvements in mass spectrometry have made lipidomics a …

Effect of Endosulfan Organochlorine-based Insecticide on Human Mental Health at the Molecular Level using Panther

D Sharma, T Shiri, A Kapri, V Sharma - Analytical Chemistry …, 2021 - Taylor & Francis
Endosulfan is an organochlorine insecticide that is extensively used in agriculture. Humans
get exposed to this contaminant either directly through farms or indirectly by consumption of …

Prospects and limitations of physiologically-based pharmacokinetic modelling for cross-species extrapolation

L Kuepfer - SVU-International Journal of Veterinary Sciences, 2019 - journals.ekb.eg
The transition from experimental findings in animal models to clinical applications in human
patients is a key challenge in pharmacology and toxicology. To date, this steps still inhibits a …

[HTML][HTML] Sub-lethal effects of calcium dinonylnaphthalenesulfonate on Western clawed frog embryos

SJ Wallace, AJA Leclerc, R Prosser… - … and Physiology Part D …, 2020 - Elsevier
Naphthalene sulfonic acids (NSAs) are used as additives in lubricants, dyes, and greases
and commonly act as surfactants in many industrial processes. The calcium salt of dinonyl …

Drug development

FI Raynaud - Metabolomics for Biomedical Research, 2020 - Elsevier
Successful drug discovery relies on understanding disease causality and identifying a
druggable target for therapeutic intervention. Metabolomics is a welcome complement to …

Toxicopanomics: Application of Genomics, Transcriptomics, Proteomics, Metabolomics, and Lipidomics in Predictive Mechanistic Toxicology

MA Choukrallah, M Talikka, S Boue… - … and Methods of …, 2023 - books.google.com
Systems toxicology is a subdiscipline of systems biology that aims to provide a holistic view
of biological processes by using systems-wide molecular measurements, which are …