CRISPR-based drugs can theoretically manipulate any genetic target. In practice, however,
these drugs must enter the desired cell without eliciting an unwanted immune response, so …

Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …

The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Omicron sublineages, including the BA. 2-derived BA. 2.75. 2 and the BA. 5-derived BQ. 1.1 …

Substantial Neutralization Escape by SARS-CoV-2 Omicron Variants BQ.1.1 and XBB.1 | New
England Journal of Medicine Skip to main content The New England Journal of Medicine …

The heterogeneity of the SARS-CoV-2 immune responses has become considerably more
complex over time and diverse immune imprinting is observed in vaccinated individuals …

Neutralization Escape by SARS-CoV-2 Omicron Subvariant BA.4.6 | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

There is growing concern that Coronavirus Disease 2019 (COVID-19) vaccine fatigue will be
a major obstacle in maintaining immunity in the general population. In this study, we …

Vaccine protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection wanes over time, requiring updated boosters. In a phase 2, open-label, randomized …

ABSTRACT The highly mutated BA. 2.86, with over 30 spike protein mutations in
comparison to Omicron BA. 2 and XBB. 1.5 variants, has raised concerns about its potential …

Worldwide there have been over 760 million confirmed coronavirus disease 2019 (COVID-
19) cases, and over 13 billion COVID-19 vaccine doses have been administered as of April …