The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

Post-translational modifications of histones regulate all DNA-templated processes, including
replication, transcription and repair. These modifications function as platforms for the …

Abstract FACT (FAcilitates Chromatin Transcription) has long been considered to be a
transcription elongation factor whose ability to destabilize nucleosomes promotes RNAPII …

Stability and function of eukaryotic genomes are closely linked to chromatin structure and
organization. During cell division the entire genome must be accurately replicated and the …

In eukaryotes, DNA compacts into chromatin through nucleosomes,. Replication of the
eukaryotic genome must be coupled to the transmission of the epigenome encoded in the …

The functional organization of eukaryotic DNA into chromatin uses histones as components
of its building block, the nucleosome. Histone chaperones, which are proteins that escort …

In the history of science and technology, researchers have always undertaken endeavors to
enhance the degree of “directness of measurement”. With “directness of measurement”, we …

Heterochromatin, defined by histone H3 lysine 9 methylation (H3K9me), spreads across
large domains and can be epigenetically inherited in a self-propagating manner …

Regulation of gene transcription is vitally important for the maintenance of normal cellular
homeostasis. Failure to correctly regulate gene expression, or to deal with problems that …

Nucleosomes are decorated with numerous post-translational modifications capable of
influencing many DNA processes. Here we describe a new class of histone modification …