Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Environmental challenges are part of daily life for any individual. In fact, stress appears to be
increasingly present in our modern, and demanding, industrialized society. Virtually every …

The impairment of hippocampal neurogenesis at the early stages of Alzheimer's disease
(AD) is believed to support early cognitive decline. Converging studies sustain the idea that …

Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a
high prevalence among the elderly and a huge personal and societal impact. Recent …

Exposure to stress during the sensitive period of early-life increases the risk to develop
cognitive impairments and psychopathology later in life. In addition, early-life stress (ES) …

Curcumin is a natural polyphenol with evidence of antioxidant, anti-inflammatory and
neuroprotective properties. Recent evidence also suggests that curcumin increases …

Alzheimer's disease (AD) is a common neurodegenerative disorder that presents with
cognitive impairment and behavioral disturbance. Approximately 5.5 million people in the …

Abstract Fragile X Syndrome (FXS) is the most common heritable form of mental retardation
and monogenic cause of autism spectrum disorder (ASD). FXS is due to a mutation in the X …

Alzheimer's disease (AD) is of multifactorial origin, and still presents several gaps regarding
its development and progression. Disorders of the cholinergic system are well known to be …

Enhancement of central availability of the second messenger cAMP is a promising approach
to improve cognitive function. Pharmacological inhibition of phosphodiesterase type 4 …