Glycosylation is a well-regulated cell and microenvironment specific post-translational
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …

Brain metastasis (BM) is the most common event in patients with lung cancer. Despite
multimodal treatments and advances in systemic therapies, development of BM remains one …

Intratumor heterogeneity (ITH) is a biomarker of tumor progression, metastasis, and immune
evasion. Previous studies evaluated ITH mostly based on DNA alterations. Here, we …

Background Tumor mutation burden (TMB) has been recognized as a predictive biomarker
for immunotherapy response in cancer. Systematic identification of molecular features …

Metastasis is the leading cause of melanoma-related mortality. Current therapies are rarely
curative for metastatic melanoma, revealing the urgent need to identify more effective …

Central nervous system (CNS) metastases are common in non-small-cell lung cancer
(NSCLC) and associated with poor prognosis and high disease burden. Effective options …

Background: Brain metastases (BMs) is one of the most frequent metastatic sites for non-
small-cell lung cancer (NSCLC). It is a matter of debate whether EGFR mutation in the …

Blacks have the highest incidence and mortality from most cancers. The reasons for these
disparities remain unclear. Blacks are exposed to adverse social determinants because of …

Aim: We aimed to evaluate the prognostic values of neutrophil-to-lymphocyte ratio (NLR),
platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR) and systemic …

Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors and has
high morbidity and mortality rates. Central nervous system (CNS) metastasis is one of the …