Bushen-Yizhi formula exerts neuroprotective effect via inhibiting excessive mitophagy in rats with chronic cerebral hypoperfusion

Q Xiao, H Liu, C Yang, Y Chen, Y Huang, X Xiao… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Bushen-Yizhi formula (BSYZ), a traditional
Chinese medicine (TCM) prescription widely used in treating mental retardation and …

PAE ameliorates doxorubicin-induced cardiotoxicity via suppressing NHE1 phosphorylation and stimulating PI3K/AKT phosphorylation

Y Yin, Q Niu, H Hou, H Que, S Mi, J Yang, Z Li… - International …, 2022 - Elsevier
Abstract Doxorubicin (DOX), a broad-spectrum anti-tumor drug, has severe cardiotoxic side
effects that limit its clinical application. Perillaldehyde (PAE) is the main component of …

[HTML][HTML] Apocynum venetum, a medicinal, economical and ecological plant: a review update

T Xiang, L Wu, MB Isah, C Chen, X Zhang - PeerJ, 2023 - peerj.com
Apocynum venetum L. is an important medicinal perennial rhizome plant with good
ecological and economic value. Its leaves have many pharmacological effects such as anti …

Unlocking the Potential: Quercetin and Its Natural Derivatives as Promising Therapeutics for Sepsis

T Wang, L Lv, H Feng, W Gu - Biomedicines, 2024 - mdpi.com
Sepsis is a syndrome of organ dysfunction caused by an uncontrolled inflammatory
response, which can seriously endanger life. Currently, there is still a shortage of specific …

Chemical constituents from the flowers of Cynanchum auriculatum Royle ex Wight

X Ding, L Wang, Y Xu, S Zheng, S Wang… - Biochemical Systematics …, 2023 - Elsevier
The present work was undertaken to investigate chemical constituents and chemotaxonomic
significance from the flowers of Cynanchum auriculatum Royle ex Wight (C. auriculatum) by …

Protective effect of vitamin B6 against doxorubicin‐induced cardiotoxicity by modulating NHE1 expression

R Sun, H Wang, Z Gui, L Lin, J Fan… - … of Biochemical and …, 2023 - Wiley Online Library
Doxorubicin (DOX) has been used to treat various types of cancer, but its application is
limited due to its heart toxicity as well as other drawbacks. Chronic inhibition of Na+/H+ …

[HTML][HTML] Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells

YS Sun, ZW Wang, Z Gao, W Zhao, K Thakur… - Current Research in …, 2022 - Elsevier
In this study, Hawthorn oligomic procyanidins extracts (HPOE) were evaluated for their
anticancer activity on colorectal cancer. Our results showed that HPOE arrested HCT116 …

Pharmacokinetics integrated with network pharmacology to clarify effective components and mechanism of Wendan decoction for the intervention of coronary heart …

P Lin, L Hu, Q Huang, Y Zhang, Z Qin, J Chen… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Coronary heart disease (CHD), one of the leading causes
of mortality in the world among chronic non-infectious diseases, is closely associated with …

[HTML][HTML] Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity by regulating organic acid metabolism in gut microbiota

Z Zhao, S Jiang, Q Fan, K Xu, Y Xu, F Wu… - Frontiers in …, 2023 - frontiersin.org
Apocynum venetum leaf is commonly utilized for its beneficial effects in reducing blood
pressure, inducing sedation, promoting diuresis, anti-aging, and cardioprotection, which …

[HTML][HTML] Genome-wide identification and expression analysis of the PP2C gene family in Apocynum venetum and Apocynum hendersonii

J Chen, Y Wang, Y Wu, X Huang, X Qiu, J Chen… - BMC Plant …, 2024 - Springer
Background Protein phosphatase class 2 C (PP2C) is the largest protein phosphatase family
in plants. Members of the PP2C gene family are involved in a variety of physiological …