Until recently it was believed that no more than 1% of the general population has bipolar
disorder. Emerging transatlantic data are beginning to provide converging evidence for a …

Objectives: Although clinically highly relevant, the recognition and treatment of bipolar mixed
states has played only an underpart in recent guidelines. This WFSBP guideline has been …

BACKGROUND: The nosologic status of agitated depression is unresolved. Are they
unipolar (UP) or bipolar (BP)? Are they mixed states? Even more controversial is the notion …

Objective: Little is known about how often bipolar depressive episodes are accompanied by
subsyndromal manic symptoms in bipolar I and II disorders. The authors sought to determine …

Background: Episode duration, recurrence rates, and time spent in manic and depressive
phases of bipolar disorder (BD) is not well defined for subtypes of the disorder. Methods: We …

Objective Episodes of bipolar disorder are defined as depressive or manic, but depressive
and manic symptoms can combine in the same episode. Coexistence or rapid alternation of …

Tondo L, Vázquez G, Baldessarini RJ. Mania associated with antidepressant treatment:
comprehensive meta‐analytic review. Objective: To review available data pertaining to risk …

Objective: To determine whether men and women with bipolar disorder differ in age of onset,
course of illness, number of suicide attempts, comorbidity rates and symptom presentation …

BACKGROUND: Previous reports have shown a significant relationship between suicide
ideation and mixed depression. The aim of this study was to explore the prevalence and …

Objective To review the DSM‐5 proposed criteria for mixed depression in light of robust and
consistent historical and scientific evidence. Method An extensive historical search, a …