Pathways of antigen processing
JS Blum, PA Wearsch… - Annual review of …, 2013 - annualreviews.org
T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …
Towards a systems understanding of MHC class I and MHC class II antigen presentation
J Neefjes, MLM Jongsma, P Paul… - Nature reviews …, 2011 - nature.com
The molecular details of antigen processing and presentation by MHC class I and class II
molecules have been studied extensively for almost three decades. Although the basic …
molecules have been studied extensively for almost three decades. Although the basic …
Variations in MHC class II antigen processing and presentation in health and disease
ER Unanue, V Turk, J Neefjes - Annual review of immunology, 2016 - annualreviews.org
MHC class II (MHC-II) molecules are critical in the control of many immune responses. They
are also involved in most autoimmune diseases and other pathologies. Here, we describe …
are also involved in most autoimmune diseases and other pathologies. Here, we describe …
[HTML][HTML] Type 1 diabetes and autoimmune thyroid disease—the genetic link
L Frommer, GJ Kahaly - Frontiers in endocrinology, 2021 - frontiersin.org
Type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) are the most frequent
chronic autoimmune diseases worldwide. Several autoimmune endocrine and non …
chronic autoimmune diseases worldwide. Several autoimmune endocrine and non …
Presentation of phagocytosed antigens by MHC class I and II
AR Mantegazza, JG Magalhaes, S Amigorena… - Traffic, 2013 - Wiley Online Library
Phagocytosis provides innate immune cells with a mechanism to take up and destroy
pathogenic bacteria, apoptotic cells and other large particles. In some cases, however …
pathogenic bacteria, apoptotic cells and other large particles. In some cases, however …
MHC class II antigen presentation by dendritic cells regulated through endosomal sorting
T Ten Broeke, R Wubbolts… - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
For the initiation of adaptive immune responses, dendritic cells present antigenic peptides in
association with major histocompatibility complex class II (MHCII) to naïve CD4+ T …
association with major histocompatibility complex class II (MHCII) to naïve CD4+ T …
[HTML][HTML] Optimization of the MHC class I peptide cargo is dependent on tapasin
AP Williams, CA Peh, AW Purcell, J McCluskey, T Elliott - Immunity, 2002 - cell.com
The loading of MHC class I molecules with their peptide cargo is undertaken by a
multimolecular peptide loading complex within the endoplasmic reticulum. We show that …
multimolecular peptide loading complex within the endoplasmic reticulum. We show that …
Lysosomes and lysosome‐related organelles in immune responses
C Watts - FEBS open bio, 2022 - Wiley Online Library
The catabolic, degradative capacity of the endo‐lysosome system is put to good use in
mammalian immune responses as is their recently established status as signaling platforms …
mammalian immune responses as is their recently established status as signaling platforms …
" Tolerosomes" are produced by intestinal epithelial cells
M Karlsson, S Lundin, U Dahlgren… - European journal of …, 2001 - Wiley Online Library
The development of immunological tolerance to orally fed antigens depends on the
sampling, processing and transportation events followed in the intestinal epithelium. We …
sampling, processing and transportation events followed in the intestinal epithelium. We …
Class II MHC antigen processing in immune tolerance and inflammation
MM Jurewicz, LJ Stern - Immunogenetics, 2019 - Springer
Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …