T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

The molecular details of antigen processing and presentation by MHC class I and class II
molecules have been studied extensively for almost three decades. Although the basic …

MHC class II (MHC-II) molecules are critical in the control of many immune responses. They
are also involved in most autoimmune diseases and other pathologies. Here, we describe …

Type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) are the most frequent
chronic autoimmune diseases worldwide. Several autoimmune endocrine and non …

Phagocytosis provides innate immune cells with a mechanism to take up and destroy
pathogenic bacteria, apoptotic cells and other large particles. In some cases, however …

For the initiation of adaptive immune responses, dendritic cells present antigenic peptides in
association with major histocompatibility complex class II (MHCII) to naïve CD4+ T …

The loading of MHC class I molecules with their peptide cargo is undertaken by a
multimolecular peptide loading complex within the endoplasmic reticulum. We show that …

The catabolic, degradative capacity of the endo‐lysosome system is put to good use in
mammalian immune responses as is their recently established status as signaling platforms …

The development of immunological tolerance to orally fed antigens depends on the
sampling, processing and transportation events followed in the intestinal epithelium. We …

Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …