Recent technological advances have stimulated efforts to bring personalized medicine into
practice. Yet, traditional application fields like therapeutic drug monitoring (TDM) have …

Antibiotics were initially natural substances. However, nowadays, they also include synthetic
drugs, which show their activity against bacteria, killing or inhibiting their growth and …

Purpose Standard dosing and intermittent bolus application (IB) are important risk factors for
pharmacokinetic (PK) target non-attainment during empirical treatment with β-lactams in …

Application of Sustainable analytical chemistry concepts has become crucial in order to
remove the environmentally harmful impacts originating from the routine use of analytical …

Background Systemically administered antibiotics are thought to penetrate the wounds more
effectively during negative pressure wound therapy (NPWT). To test this hypothesis total and …

Our study aimed to describe the population pharmacokinetics (PK) of piperacillin and
tazobactam in patients on extracorporeal membrane oxygenation (ECMO), with and without …

Quantification of beta-lactam antibiotics can be performed by using liquid chromatography in
combination with tandem mass spectrometry (MS/MS) or ultraviolet (UV) detection. Since …

The common practice of therapeutic drug monitoring (TDM) involves the quantification of
drug plasma concentrations at a specific time in a dosing window. Although TDM for …

Background: The antibacterial effect of antibiotics is linked to the free drug concentration.
This study investigated the applicability of an ultrafiltration method to determine free plasma …

Antibiotics are widely used in intensive care patients to treat severe infections. To avoid
bacterial resistance or toxic side effects, the determination of serum concentration of ABs is …