Early-Onset Colorectal Cancer Early-onset disease (at< 50 years of age) accounts for 10%
of colorectal cancer cases, and the incidence is increasing, particularly in high-income …

Oncogenesis is associated with intestinal dysbiosis, and stool shotgun metagenomic
sequencing in individuals with this condition might constitute a non-invasive approach for …

Epidemiologic data indicate a significant increase in the incidence of colorectal cancer in
younger populations in the past three decades. Moreover, recent evidence also …

Objective The incidence of early-onset colorectal cancer (EO-CRC) is steadily increasing.
Here, we aimed to characterise the interactions between gut microbiome, metabolites and …

Gut microbiota‐derived metabolites are key hubs connecting the gut microbiome and cancer
progression, primarily by remodeling the tumor microenvironment and regulating key …

Colorectal cancer (CRC) is the third most common malignant tumor worldwide. The
incidence and mortality rates of CRC have been increasing in China, possibly due to …

Maladaptation of host-microbiota metabolic interplay plays a critical role in colorectal cancer
initiation. Here, through a combination of single-cell transcriptomics, microbiome profiling …

Background The gut microbiome is closely related to gastrointestinal (GI) cancer, but the
causality of gut microbiome with GI cancer has yet to be fully established. We conducted this …

Colorectal cancer is the second leading cause of cancer-related mortality worldwide.
Numerous pathophysiological mechanisms, such as abnormal cell proliferation, cell …

Environmental exposures are a major risk factor for developing colorectal cancer, and the
gut microbiome may serve as an integrator of such environmental risk. To study the …