Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …

The substantial contributions of Dr. Gerald Stern to past and current treatments for
Parkinson's disease patients are reviewed, which form the foundation for an evaluation of …

Abstract Paraoxonase-1 (PON1), an esterase/lactonase primarily associated with plasma
high-density lipoprotein (HDL), was the first member of this family of enzymes to be …

In addition to increased morbidity and mortality caused by respiratory and cardiovascular
diseases, air pollution may also contribute to central nervous system (CNS) diseases. Traffic …

Aging is defined as the accumulation of progressive organ dysfunction. There is much
evidence linking the involvement of oxidative stress in the pathogenesis of aging. With …

The human body has biological redox systems capable of preventing or mitigating the
damage caused by increased oxidative stress throughout life. One of them are the …

Abstract Paraoxonase 2 (PON2) is a ubiquitously expressed intracellular enzyme that is
known to have a protective role from oxidative stress. Clinical studies have also …

Paraoxonase enzymes serve as an important physiological redox system that participates in
the protection against cellular injury caused by oxidative stress. The PON enzymes family …

Neurodegenerative disorders (NDDs) are characterized by progressive loss of selectively
vulnerable neuronal populations and myelin sheath, leading to behavioral and cognitive …

Paraoxonase-2 regulates reactive oxygen species production in mitochondria. Stimulating
its expression has therapeutic potential for diseases where oxidative stress plays a …