Abstract Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of
haem, is primarily considered an antioxidant, and has long been overlooked by …

Heme-oxygenase is the enzyme responsible for degradation of endogenous iron
protoporphyirin heme; it catalyzes the reaction's rate-limiting step, resulting in the release of …

Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

Oxidative stress (OS) plays a critical role in the pathophysiology of several brain-related
disorders, including neurodegenerative diseases and ischemic stroke, which are the major …

The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …

Under stressful conditions, cellular heme catabolism to carbon monoxide, iron and biliverdin
is mediated by the 32 kDa enzyme, heme oxygenase-1 (HO-1). A wide range of pro-oxidant …

This review is intended to stimulate interest in the effect of increased expression of heme
oxygenase-1 (HO-1) protein and increased levels of HO activity on normal and pathological …

There is a growing body of evidence to support a role for oxidative stress in Alzheimer's
disease (AD), with increased levels of lipid peroxidation, DNA and protein oxidation …

J. Neurochem.(2011) 118, 939–957. Abstract Alterations of iron levels in the brain has been
observed and documented in a number of neurodegenerative disorders including …

Neurodegenerative diseases share various pathological features, such as accumulation of
aberrant protein aggregates, microglial activation, and mitochondrial dysfunction. These …