Tumor neoantigens: building a framework for personalized cancer immunotherapy
It is now well established that the immune system can recognize developing cancers and
that therapeutic manipulation of immunity can induce tumor regression. The capacity to …
that therapeutic manipulation of immunity can induce tumor regression. The capacity to …
Peptide vaccine: progress and challenges
Conventional vaccine strategies have been highly efficacious for several decades in
reducing mortality and morbidity due to infectious diseases. The bane of conventional …
reducing mortality and morbidity due to infectious diseases. The bane of conventional …
Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia
M Rajasagi, SA Shukla, EF Fritsch… - Blood, The Journal …, 2014 - ashpublications.org
Genome sequencing has revealed a large number of shared and personal somatic
mutations across human cancers. In principle, any genetic alteration affecting a protein …
mutations across human cancers. In principle, any genetic alteration affecting a protein …
Computational immunology meets bioinformatics: the use of prediction tools for molecular binding in the simulation of the immune system
We present a new approach to the study of the immune system that combines techniques of
systems biology with information provided by data-driven prediction methods. To this end …
systems biology with information provided by data-driven prediction methods. To this end …
Peptide binding predictions for HLA DR, DP and DQ molecules
Background MHC class II binding predictions are widely used to identify epitope candidates
in infectious agents, allergens, cancer and autoantigens. The vast majority of prediction …
in infectious agents, allergens, cancer and autoantigens. The vast majority of prediction …
Reverse vaccinology: developing vaccines in the era of genomics
A Sette, R Rappuoli - Immunity, 2010 - cell.com
The sequence of microbial genomes made all potential antigens of each pathogen available
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction
Human leukocyte antigen class I (HLA-I) molecules are encoded by major histocompatibility
complex (MHC) class I loci in humans. The binding and interaction between HLA-I …
complex (MHC) class I loci in humans. The binding and interaction between HLA-I …
NetMHCcons: a consensus method for the major histocompatibility complex class I predictions
A key role in cell-mediated immunity is dedicated to the major histocompatibility complex
(MHC) molecules that bind peptides for presentation on the cell surface. Several in silico …
(MHC) molecules that bind peptides for presentation on the cell surface. Several in silico …
The length distribution of class I–restricted T cell epitopes is determined by both peptide supply and MHC allele–specific binding preference
HLA class I–binding predictions are widely used to identify candidate peptide targets of
human CD8+ T cell responses. Many such approaches focus exclusively on a limited range …
human CD8+ T cell responses. Many such approaches focus exclusively on a limited range …
Immunoinformatics and epitope prediction in the age of genomic medicine
L Backert, O Kohlbacher - Genome medicine, 2015 - Springer
Immunoinformatics involves the application of computational methods to immunological
problems. Prediction of B-and T-cell epitopes has long been the focus of immunoinformatics …
problems. Prediction of B-and T-cell epitopes has long been the focus of immunoinformatics …