According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Peptide‐centered shotgun analysis of proteins has been the core technology in mass
spectrometry based proteomics and has enabled numerous biological discoveries, such as …

A readily distinguishable and indigenous member of the plant kingdom in the Indian
subcontinent is the 'drumstick tree', ie Moringa oleifera Lam. In addition to India, this drought …

Biotechnology increasingly delivers highly promising protein-based biopharmaceutical
candidates to the drug development funnel. For successful biopharmaceutical drug …

Post-translational modifications (PTMs) occur on nearly all proteins. Many domains within
proteins are modified on multiple amino acid sidechains by diverse enzymes to create a …

Mass spectrometry (MS)-based proteomics workflows can crudely be classified into two
distinct regimes, targeting either relatively small peptides (ie, 0.7 kDa< M w< 3.0 kDa) or …

We recently introduced a novel scheme combining electron-transfer and higher-energy
collision dissociation (termed EThcD), for improved peptide ion fragmentation and …

High‐performance liquid chromatography integrated with tandem mass spectrometry (HPLC–
MS/MS) has become a powerful technique for proteomics research. Its performance heavily …

Proteomics is a large-scale study of proteins, aiming at the description and characterization
of all expressed proteins in biological systems. The expressed proteins are typically highly …

Proteomics is acquiring a pivotal role in the comprehensive understanding of human
biology. Biochemical processes involved in complex diseases, such as neurodegenerative …