[HTML][HTML] Essential metals in health and disease

K Jomova, M Makova, SY Alomar, SH Alwasel… - Chemico-biological …, 2022 - Elsevier
In total, twenty elements appear to be essential for the correct functioning of the human
body, half of which are metals and half are non-metals. Among those metals that are …

Prescribed drugs containing nitrogen heterocycles: an overview

MM Heravi, V Zadsirjan - RSC advances, 2020 - pubs.rsc.org
Heteroatoms as well as heterocyclic scaffolds are frequently present as the common cores in
a plethora of active pharmaceuticals natural products. Statistically, more than 85% of all …

From purines to purinergic signalling: molecular functions and human diseases

Z Huang, N Xie, P Illes, F Di Virgilio, H Ulrich… - … and Targeted Therapy, 2021 - nature.com
Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

[HTML][HTML] Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis

J Wu, Z Wei, P Cheng, C Qian, F Xu, Y Yang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Gut microbiota, which plays a crucial role in inflammatory bowel diseases
(IBD), might have therapeutic benefits for ulcerative colitis or Crohn's disease. Targeting gut …

Sources of vascular nitric oxide and reactive oxygen species and their regulation

J Tejero, S Shiva, MT Gladwin - Physiological reviews, 2019 - journals.physiology.org
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Oxidative stress in preeclampsia and placental diseases

R Aouache, L Biquard, D Vaiman… - International journal of …, 2018 - mdpi.com
Preeclampsia is a persistent hypertensive gestational disease characterized by high blood
pressure and proteinuria, which presents from the second trimester of pregnancy. At the …

5-Hydroxymethylfurfural (HMF) levels in honey and other food products: effects on bees and human health

UM Shapla, M Solayman, N Alam, MI Khalil… - Chemistry central …, 2018 - Springer
An organic compound known as 5-hydroxymethylfurfural (HMF) is formed from reducing
sugars in honey and various processed foods in acidic environments when they are heated …

The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal–fetal homeostasis

N Gomez-Lopez, J Galaz, D Miller… - …, 2022 - rep.bioscientifica.com
In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …

Curcumin: an inflammasome silencer

S Hasanzadeh, MI Read, AR Bland, M Majeed… - Pharmacological …, 2020 - Elsevier
Curcumin is the major bioactive polyphenolic ingredient of turmeric. Increasing evidence
indicates that the health benefits of curcumin are mediated through its anti-inflammatory and …

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

ET Chouchani, VR Pell, E Gaude, D Aksentijević… - Nature, 2014 - nature.com
Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and
then restored, and underlies many disorders, notably heart attack and stroke. While …