Children from pregnant smokers are more susceptible to become obese adults and to
become drug or food addicts. Drugs and food activate the mesolimbic reward pathway …

Serotonin (5-HT) plays an underpinning role in appetite regulation and the opioid system
has a role in the modulation of the ingestion behavior in birds. The current survey was aimed …

The repeated cycles of cessation of consumption and relapse remain the major clinical
concern in treating drug addiction. The endogenous opioid system is a crucial component of …

Aim This study aimed to determine whether the negative effects of maternal 'junk
food'feeding on food preferences and gene expression in the mesolimbic reward system …

The incidence of obesity in both adults and children is rising. In order to develop effective
treatments for obesity, it is important to understand how diet can induce changes in the brain …

μ-opioid receptors (MORs) in the nucleus accumbens (NAc) can regulate reward-related
behaviors that are dependent on mesolimbic dopamine, but the precise mechanism of this …

Binge eating disorders are characterized by episodes of intense consumption of high-calorie
food. In recently developed animal models of binge eating, rats given intermittent access to …

OBJECTIVE: One developing strategy for obesity treatment has been to use combinations of
differently acting pharmacotherapies to improve weight loss with fewer adverse effects. The …

The dynorphin peptides are the endogenous ligands for the kappa opioid receptor (KOR)
and regulate food intake. Administration of dynorphin-A 1-13 (DYN) in the paraventricular …

Obesity and eating disorders are widespread in Western societies. Both the increased
availability of highly palatable foods and dieting are major risk factors contributing to the …