Vascular cognitive impairment (VCI) is predominately caused by vascular risk factors and
cerebrovascular disease. VCI includes a broad spectrum of cognitive disorders, from mild …

Cerebral small vessel disease (SVD) is commonly observed on neuroimaging among
elderly individuals and is recognized as a major vascular contributor to dementia, cognitive …

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance
imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral …

Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …

Background White matter hyperintensities (WMH) are very frequent in older adults and
associated with worse cognitive performance. Little is known about the links between WMH …

Background and Objectives Topographical distribution of white matter hyperintensities
(WMH) are hypothesized to vary by cerebrovascular risk factors. We used an unbiased …

Severe cognitive decline is a hallmark of Alzheimer's disease (AD). In addition to gray matter
loss, significant white matter pathology has been identified in AD patients. Here, we …

Background Intranasally administered insulin has shown promise in both rodent and human
studies in Alzheimer's disease; however, both effects and mechanisms require elucidation …

The clinical diagnosis of vascular dementia (VaD) is based on imaging criteria, and specific
biochemical markers are not available. Here, we investigated the potential of cerebrospinal …

Objective Recent studies suggest that white matter hyperintensities (WMH) on MRI, which
primarily reflect small vessel cerebrovascular disease, may play a role in the evolution of …