White matter hyperintensities and CSF Alzheimer disease biomarkers in preclinical Alzheimer disease

A Soldan, C Pettigrew, Y Zhu, MC Wang, A Moghekar… - Neurology, 2020 - AAN Enterprises
Objective Recent studies suggest that white matter hyperintensities (WMH) on MRI, which
primarily reflect small vessel cerebrovascular disease, may play a role in the evolution of …

White matter hyperintensities in Alzheimer's disease: Beyond vascular contribution

A Garnier‐Crussard, F Cotton… - Alzheimer's & …, 2023 - Wiley Online Library
White matter hyperintensities (WMH), frequently seen in older adults, are usually considered
vascular lesions, and participate in the vascular contribution to cognitive impairment and …

[HTML][HTML] Cerebral small vessel disease in sporadic and familial Alzheimer disease

RN Kalaria, D Sepulveda-Falla - The American journal of pathology, 2021 - Elsevier
Alzheimer disease (AD) is the most common cause of dementia. Biological definitions of AD
are limited to the cerebral burden of amyloid β plaques, neurofibrillary pathology, and …

Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer's disease

M Gaubert, C Lange, A Garnier-Crussard… - Alzheimer's Research & …, 2021 - Springer
Background White matter hyperintensities (WMH) are frequently found in Alzheimer's
disease (AD). Commonly considered as a marker of cerebrovascular disease, regional …

Gut microbiome predicts cognitive function and depressive symptoms in late life

A Kolobaric, C Andreescu, E Jašarević, CH Hong… - Molecular …, 2024 - nature.com
Depression in older adults with cognitive impairment increases progression to dementia.
Microbiota is associated with current mood and cognition, but the extent to which it predicts …

White matter hyperintensities and their relationship to cognition: Effects of segmentation algorithm

MA Tubi, FW Feingold, D Kothapalli, ET Hare, KS King… - Neuroimage, 2020 - Elsevier
White matter hyperintensities (WMHs) are brain white matter lesions that are hyperintense
on fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) scans …

Hypertension and Alzheimer's disease: is the picture any clearer?

MJ Lennon, R Koncz, PS Sachdev - Current opinion in psychiatry, 2021 - journals.lww.com
Hypertension and Alzheimer's disease: is the picture any cle... : Current Opinion in
Psychiatry Hypertension and Alzheimer's disease: is the picture any clearer? : Current …

The association between white matter hyperintensities and amyloid and tau deposition

SL Alban, KM Lynch, JM Ringman, AW Toga… - NeuroImage: Clinical, 2023 - Elsevier
White matter hyperintensities (WMHs) frequently occur in Alzheimer's Disease (AD) and
have a contribution from ischemia, though their relationship with β-amyloid and …

Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals

A Brugulat-Serrat, G Salvadó, CH Sudre… - Brain imaging and …, 2020 - Springer
White matter hyperintensities (WMH) are commonly detected in the brain of elderly
individuals and have been associated with a negative impact on multiple cognitive domains …

A population neuroscience approach to the study of cerebral small vessel disease in midlife and late life: an invited review

DR Jorgensen, CE Shaaban… - American Journal …, 2018 - journals.physiology.org
Aging in later life engenders numerous changes to the cerebral microvasculature. Such
changes can remain clinically silent but are associated with greater risk for negative health …