The pathogenesis of white matter hyperintensities (WMH) is incompletely understood but
blood–brain barrier (BBB) dysfunction may play a key role. This study aimed to investigate …

Abstract Objective: Intraindividual variability (IIV), generally defined as short-term variations
in behavior, has been proposed as a sign of subtle early impairment in neurodegenerative …

Alzheimer's disease (AD) is the most common cause of dementia, characterized by the
aggregation of amyloid-beta (Aβ) proteins into plaques. Individuals with AD frequently show …

The association between white matter hyperintensities (WMH) and amyloid accumulation
over time in cognitively normal, amyloid-negative elderly people remains largely …

Whether a relationship exists between cerebrovascular disease and Alzheimer's disease
has been a source of controversy. Evaluation of the temporal progression of imaging …

Oligodendrocytes are in contact with neurons, wrap axons with a myelin sheath that protects
their structural integrity, and facilitate nerve conduction. Oligodendrocytes also form a …

The risk of seizures is 10-fold higher in patients with Alzheimer's disease than the general
population, yet the mechanisms underlying this susceptibility and the effects of these …

This study investigated the relationship between white matter hyperintensities (WMH) and
cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. Subjects included 180 …

White matter hyperintensities (WMHs) have a heterogeneous aetiology, associated with both
vascular risk factors and amyloidosis due to Alzheimer's disease. While spatial distribution of …

Objective To evaluate the association between brain amyloid β (Aβ) and cerebral small
vessel disease (CSVD) markers, as well as their joint effect on cognition, in a memory clinic …