Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …

Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …

Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …

THE major active ingredient of marijuana, Δ9-tetrahydrocannabi-nol (Δ9-THC), has been
used as a psychoactive agent for thousands of years. Marijuana, and Δ9-THC, also exert a …

We developed PolyA-seq, a strand-specific and quantitative method for high-throughput
sequencing of 3′ ends of polyadenylated transcripts, and used it to globally map …

Abstract Polyadenylation [poly (A)] signals (PAS) are a defining feature of eukaryotic protein-
coding genes. The central sequence motif AAUAAA was identified in the mid-1970s and …

We have examined the prothrombin gene as a candidate gene for venous thrombosis in
selected patients with a documented familial history of venous thrombophilia. All the exons …

Abstract mRNA polyadenylation is a critical cellular process in eukaryotes. It involves 3′
end cleavage of nascent mRNAs and addition of the poly (A) tail, which plays important roles …

A goal of human genetics studies is to determine the mechanisms by which genetic variation
produces phenotypic differences that affect human health. Efforts in this respect have …

Formation of mRNA 3′ ends in eukaryotes requires the interaction of transacting factors
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …