Alternative cleavage and polyadenylation in health and disease
Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …
can occur, enabling the expression of distinct transcript isoforms under different conditions …
Alternative polyadenylation of mRNA precursors
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
[HTML][HTML] 3′-end processing of eukaryotic mRNA: machinery, regulation, and impact on gene expression
V Boreikaitė, LA Passmore - Annual review of biochemistry, 2023 - annualreviews.org
Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …
transcript. This process is mediated by a number of protein factors that cleave the pre …
Molecular characterization of a peripheral receptor for cannabinoids
THE major active ingredient of marijuana, Δ9-tetrahydrocannabi-nol (Δ9-THC), has been
used as a psychoactive agent for thousands of years. Marijuana, and Δ9-THC, also exert a …
used as a psychoactive agent for thousands of years. Marijuana, and Δ9-THC, also exert a …
A quantitative atlas of polyadenylation in five mammals
A Derti, P Garrett-Engele, KD MacIsaac… - Genome …, 2012 - genome.cshlp.org
We developed PolyA-seq, a strand-specific and quantitative method for high-throughput
sequencing of 3′ ends of polyadenylated transcripts, and used it to globally map …
sequencing of 3′ ends of polyadenylated transcripts, and used it to globally map …
[HTML][HTML] Ending the message: poly (A) signals then and now
NJ Proudfoot - Genes & development, 2011 - genesdev.cshlp.org
Abstract Polyadenylation [poly (A)] signals (PAS) are a defining feature of eukaryotic protein-
coding genes. The central sequence motif AAUAAA was identified in the mid-1970s and …
coding genes. The central sequence motif AAUAAA was identified in the mid-1970s and …
A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous …
SR Poort, FR Rosendaal, PH Reitsma, RM Bertina - 1996 - ashpublications.org
We have examined the prothrombin gene as a candidate gene for venous thrombosis in
selected patients with a documented familial history of venous thrombophilia. All the exons …
selected patients with a documented familial history of venous thrombophilia. All the exons …
A large-scale analysis of mRNA polyadenylation of human and mouse genes
B Tian, J Hu, H Zhang, CS Lutz - Nucleic acids research, 2005 - academic.oup.com
Abstract mRNA polyadenylation is a critical cellular process in eukaryotes. It involves 3′
end cleavage of nascent mRNAs and addition of the poly (A) tail, which plays important roles …
end cleavage of nascent mRNAs and addition of the poly (A) tail, which plays important roles …
The roles of RNA processing in translating genotype to phenotype
KS Manning, TA Cooper - Nature reviews Molecular cell biology, 2017 - nature.com
A goal of human genetics studies is to determine the mechanisms by which genetic variation
produces phenotypic differences that affect human health. Efforts in this respect have …
produces phenotypic differences that affect human health. Efforts in this respect have …
Formation of mRNA 3′ ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis
J Zhao, L Hyman, C Moore - Microbiology and molecular biology …, 1999 - Am Soc Microbiol
Formation of mRNA 3′ ends in eukaryotes requires the interaction of transacting factors
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …