Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies

N Kumari, SH Choi - Journal of Experimental & Clinical Cancer Research, 2022 - Springer
Cancer immunotherapy has emerged as a novel cancer treatment, although recent
immunotherapy trials have produced suboptimal outcomes, with durable responses seen …

The role of macrophages in cancer development and therapy

E Cendrowicz, Z Sas, E Bremer, TP Rygiel - Cancers, 2021 - mdpi.com
Simple Summary Tumor-Associated Macrophages (TAMs) play an important role in the
development of tumors, modulation of neoangiogenesis, immune suppression, and …

M1/M2 macrophages and their overlaps–myth or reality?

Z Strizova, I Benesova, R Bartolini… - Clinical …, 2023 - portlandpress.com
Macrophages represent heterogeneous cell population with important roles in defence
mechanisms and in homoeostasis. Tissue macrophages from diverse anatomical locations …

Evaluating the polarization of tumor-associated macrophages into M1 and M2 phenotypes in human cancer tissue: technicalities and challenges in routine clinical …

SD Jayasingam, M Citartan, TH Thang… - Frontiers in …, 2020 - frontiersin.org
Tumor-associated macrophages (TAMs) as immune cells within the tumor microenvironment
have gained much interests as basic science regarding their roles in tumor progression …

Tumor immune microenvironment in head and neck cancers

SMY Chen, AL Krinsky, RA Woolaver… - Molecular …, 2020 - Wiley Online Library
Head and neck cancers are a heterogeneous group of tumors that are highly aggressive
and collectively represent the sixth most common cancer worldwide. Ninety percent of head …

Tumor-associated neutrophils and macrophages—heterogenous but not chaotic

L Wu, XHF Zhang - Frontiers in immunology, 2020 - frontiersin.org
Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) have
been extensively studied. Their pleotropic roles were observed in multiple steps of tumor …

Cancer-associated fibroblast density, prognostic characteristics, and recurrence in head and neck squamous cell carcinoma: a meta-analysis

AM Knops, A South, U Rodeck… - Frontiers in …, 2020 - frontiersin.org
Introduction The progression and clinical course of head and neck squamous cell carcinoma
(HNSCC) relies on complex interactions between cancer and stromal cells in the tumor …

Identifying potential ligand–receptor interactions based on gradient boosted neural network and interpretable boosting machine for intercellular communication …

L Peng, P Gao, W Xiong, Z Li, X Chen - Computers in Biology and Medicine, 2024 - Elsevier
Cell–cell communication is essential to many key biological processes. Intercellular
communication is generally mediated by ligand–receptor interactions (LRIs). Thus, building …

A review on the advances and challenges of immunotherapy for head and neck cancer

G Cheng, H Dong, C Yang, Y Liu, Y Wu, L Zhu… - Cancer Cell …, 2021 - Springer
Head and neck cancer (HNC), which includes lip and oral cavity, larynx, nasopharynx,
oropharynx, and hypopharynx malignancies, is one of the most common cancers worldwide …

The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors

K Hadiloo, S Taremi, M Heidari, A Esmaeilzadeh - Biomarker Research, 2023 - Springer
Today, adoptive cell therapy has many successes in cancer therapy, and this subject is
brilliant in using chimeric antigen receptor T cells. The CAR T cell therapy, with its FDA …