Prognostic value of intratumoral Fusobacterium nucleatum and association with immune-related gene expression in oral squamous cell carcinoma patients

C Neuzillet, M Marchais, S Vacher, M Hilmi… - Scientific Reports, 2021 - nature.com
Abstract Changes in the oral microbiome, particularly Fusobacterium nucleatum, are
associated with oral squamous cell carcinoma (OSCC). F. nucleatum has been reported to …

Immune-based therapies in penile cancer

VB Joshi, PE Spiess, A Necchi, CA Pettaway… - Nature Reviews …, 2022 - nature.com
Penile cancer is a rare genitourinary malignancy that is associated with poor outcomes and
severely limited therapeutic options that are generally non-curative when used to treat …

Targeted inhibition of eIF5Ahpu suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer

J Zeng, Z Ye, S Shi, Y Liang, Q Meng, Q Zhang… - Cell Death & …, 2023 - nature.com
Eukaryotic initiation factor 5A2 (eIF5A2) is overexpressed in many types of cancer, and
spermidine-mediated eIF5A hypusination (eIF5Ahpu) appears to be essential to most of …

The Roles of Tumor‐Associated Macrophages in Prostate Cancer

C Han, Y Deng, W Xu, Z Liu, T Wang… - Journal of …, 2022 - Wiley Online Library
The morbidity of prostate cancer (PCa) is rising year by year, and it has become the primary
cause of tumor‐related mortality in males. It is widely accepted that macrophages account …

Targeting the immune microenvironment in the treatment of head and neck squamous cell carcinoma

HC Wang, LP Chan, SF Cho - Frontiers in Oncology, 2019 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive solid tumor, with
a 5-year mortality rate of~ 50%. The development of immunotherapies has improved the …

Oral microbiota—A new frontier in the pathogenesis and management of head and neck cancers

M Metsäniitty, S Hasnat, T Salo, A Salem - Cancers, 2021 - mdpi.com
Simple Summary Head and neck squamous cell carcinoma (HNSCC) is a group of common
and aggressive tumors. Recently, oral microbiota has been credited as an important player …

[HTML][HTML] Macrophage secretory IL-1β promotes docetaxel resistance in head and neck squamous carcinoma via SOD2/CAT-ICAM1 signaling

CY Hsieh, CC Lin, YW Huang, JH Chen, YA Tsou… - JCI insight, 2022 - ncbi.nlm.nih.gov
Docetaxel (DTX) combined with cisplatin and 5-fluorouracil has been used as induction
chemotherapy for head and neck squamous cell carcinoma (HNSCC). However, the …

[HTML][HTML] Exosomes in cancer immunoediting and immunotherapy

Y Zhao, L Liu, R Sun, G Cui, S Guo, S Han, Z Li… - Asian journal of …, 2022 - Elsevier
As an important means of communication among cells, exosomes are being studied more
and more widely, especially in the context of cancer immunotherapy. In the phase of tumor …

Current and future biomarkers for immune checkpoint inhibitors in head and neck squamous cell carcinoma

JC Park, HN Krishnakumar, SV Saladi - Current Oncology, 2022 - mdpi.com
With the introduction of immunotherapy, significant improvement has been made in the
treatment of head and neck squamous cell carcinoma (HNSCC). However, only a small …

Macrophages in oral carcinomas: Relationship with cancer stem cell markers and PD-L1 expression

FJ Suárez-Sánchez, P Lequerica-Fernández… - Cancers, 2020 - mdpi.com
Tumor-associated macrophages (TAMs) can be polarized into antitumoral M1 and
protumoral and immunosuppressive M2 macrophages. This study investigated the clinical …