The skeleton is a common site for cancer metastases with the bone microenvironment
providing the appropriate conditions for cancer cell colonization. Once in bone, cancer cells …

Macrophages are immune cells in the TME that can not only inhibit angiogenesis,
extracellular matrix remodeling, cancer cell proliferation, and metastasis but also mediate …

Oral squamous cell carcinoma (OSCC) has a five-year survival rate of less than 50% due to
its susceptibility to invasion and metastasis. Crosstalk between tumor cells and …

Immunotherapy has emerged as a promising new treatment modality for head and neck
cancer, offering the potential for targeted and effective cancer management. Squamous cell …

Purpose: There is increasing effort to discover and integrate predictive and/or prognostic
biomarkers into treatment algorithms. While tissue-based methods can reveal tumor …

Background While immune checkpoint inhibitors (ICI) were approved for head and neck
squamous cell carcinomas (HNSCCs), the response rate remains relatively low …

Head-and-neck cancers constitute a heterogeneous group of aggressive tumors with high
incidence and low survival rates, collectively being the sixth most prevalent cancer type …

Purpose The intratumoral microenvironment of head and neck squamous cell carcinoma
(HNSC) is highly immunosuppressive. In this study, we explored the potential functional role …

Small bowel adenocarcinoma (SBA) is a gastrointestinal malignancy with low incidence but
poor prognosis, and its pathogenesis is still unclear. This study aimed to explore potential …

Simple Summary Liver stem cells and activated macrophages have been implicated as
contributors to liver cancer; hence, reducing their abundance is a potential avenue for …