Mycobacterium tuberculosis and cancer are two diseases with proclivity for the development
of resistance to the host immune system. Mechanisms behind resistance can be host …

OSCC (oral squamous cell carcinoma) is currently one of the most formidable cancers
plagued by challenges like low overall survivability, lymph node associated metastasis, drug …

Background The prevalence of HPV‐negative oropharyngeal cancer (OPC) is higher in
Asian countries. Patients with HPV‐negative OPC suffer poor outcomes. Multi‐omics …

Background As a nucleolar protein associated with ribosome biogenesis in multiple cancer
types, PES1 has been reported to be overexpressed, promoting cancer cell proliferation and …

Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family and is involved in
immune and inflammatory signaling. TYK2 is overexpressed in several types of cancers and …

Head and neck squamous cell cancer (HNSCC) is one of the ten most common malignant
neoplasms, characterized by an aggressive course, high recurrence rate, poor response to …

Head and neck squamous cell carcinoma (HNSCC), the most frequent subtype of head and
neck cancer, continues to have a poor prognosis with no improvement. The TNM stage is not …

Simple Summary Squamous cell carcinoma of the head and neck (SCCHN) is a
heterogeneous group of tumors arising from squamous cells lining different anatomic sites …

Immune checkpoint inhibition (ICI) with the PD-1 inhibitor pembrolizumab prolongs survival
for patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) in …

Background: The significance of the tumor microenvironment (TME) as a modulator of tumor
behavior was acknowledged by Hanahan and Weinberg in 2011 as the emerging hallmarks …