Introduction Cell-penetrating peptide (CPP) technologies represent an important strategy to
address drug delivery to specific intracellular compartments by covalent conjugation to …

Constructing artificial dynamic architectures inside cells to rationally interfere with organelles
is emerging as an efficient strategy to regulate the behaviors and fate of cells, thus providing …

The lack of effective treatments for neurodegenerative diseases (NDs) is an important
current concern. Lipid nanoparticles can deliver innovative combinations of active molecules …

Organelles are specialized subunits within a cell membrane that perform specific roles or
functions, and their dysfunction can lead to a variety of pathophysiologies including …

Biodegradable and adaptable polymeric materials are currently being studied due to their
wide scope of potential applications, from nanomedicine to novel multifunctional materials …

Systemic infections caused by life-threatening pathogens represent one of the main factors
leading to clinical death. In this study, we developed a pathogen infection-responsive and …

We report a scalable fabrication method to generate exosome-mimicking nanovesicles
(ENVs) by using a biocompatible, cell-binding lipid detergent during cell extrusion. A …

Cancer is a major public health problem and one of the leading causes of death. However,
traditional cancer therapy may damage normal cells and cause side effects. Many targeted …

Conventional chemotherapy for colorectal cancer (CRC), though efficacious, is discouraging
due to its limited targeting capability, lack of selectivity, and chemotherapy-associated side …

Delivering macromolecules into the cytosol or nucleus is possible in vitro for DNA, RNA and
proteins, but translation for clinical use has been limited. Therapeutic delivery of …