A successful pregnancy requires a fine-tuned and highly regulated balance between
immune activation and embryonic antigen tolerance. Since the fetus is semi-allogeneic, the …

Simple Summary The tumor immune escape mechanisms are key factors in cancer
progression and metastasis. They are an undeniable hurdle for successful cancer treatment …

Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged
receptors, a hallmark of adaptive lymphocytes. In some people infected with human …

Senescent cells accumulate in human tissues during ageing and contribute to age-related
pathologies. The mechanisms responsible for their accumulation are unclear. Here we show …

Bats harbor many viruses asymptomatically, including several notorious for causing extreme
virulence in humans. To identify differences between antiviral mechanisms in humans and …

Natural killer (NK) cells have roles in immunity and reproduction that are controlled by
variable receptors that recognize MHC class I molecules. The variable NK cell receptors …

The genetic factors associated with susceptibility or resistance to viral infections are likely to
involve a sophisticated array of immune response. These genetic elements may modulate …

The functional capacities of natural killer (NK) cells differ within and between individuals,
reflecting considerable genetic variation.'Licensing/arming','disarming', and 'tuning'are …

The activation of host's innate and adaptive immune systems can lead to acute and chronic
graft rejection, which seriously impacts graft survival. Thus, it is particularly significant to …

NK cells are emerging as new effectors for immunotherapy of cancer. In particular, the
genetic engraftment of chimeric Ag receptors (CARs) in NK cells is a promising strategy to …