Multi-adductomics: Advancing mass spectrometry techniques for comprehensive exposome characterization
Adductomics, an emerging field within the'omics sciences, focuses on the formation and
prevalence of DNA, RNA, and protein adducts induced by endogenous and exogenous …
prevalence of DNA, RNA, and protein adducts induced by endogenous and exogenous …
DNA adductomics for the biological effect assessment of contaminant exposure in marine sediments
G Martella, E Gorokhova, PFM Sousa… - Environmental …, 2023 - ACS Publications
Exposure to chemical pollution can induce genetic and epigenetic alterations,
developmental changes, and reproductive disorders, leading to population declines in …
developmental changes, and reproductive disorders, leading to population declines in …
A Novel Adductomics Workflow Incorporating FeatureHunter Software: Rapid Detection of Nucleic Acid Modifications for Studying the Exposome
Exposure to the physicochemical agents that interact with nucleic acids (NA) may lead to
modification of DNA and RNA (ie, NA modifications), which have been associated with …
modification of DNA and RNA (ie, NA modifications), which have been associated with …
Mass Spectral Library for DNA Adductomics
SJ Walmsley, J Guo, A Tarifa… - Chemical research in …, 2024 - ACS Publications
Endogenous electrophiles, ionizing and non-ionizing radiation, and hazardous chemicals
present in the environment and diet can damage DNA by forming covalent adducts. DNA …
present in the environment and diet can damage DNA by forming covalent adducts. DNA …
[HTML][HTML] Exploration and optimization of extraction, analysis and data normalization strategies for mass spectrometry-based DNA adductome mapping and modeling
M De Graeve, E Van de Walle, T Van Hecke… - Analytica Chimica …, 2023 - Elsevier
Although interest in characterizing DNA damage by means of DNA adductomics has
substantially grown, the field of DNA adductomics is still in its infancy, with room for …
substantially grown, the field of DNA adductomics is still in its infancy, with room for …
DNA Modifications: Biomarkers for the Exposome?
C Möller, J Virzi, YJ Chang, A Keidel, MR Chao… - Environmental …, 2024 - Elsevier
The concept of the exposome is the encompassing of all the environmental exposures, both
exogenous and endogenous, across the life course. Many, if not all, of these exposures can …
exogenous and endogenous, across the life course. Many, if not all, of these exposures can …
Nucleic acid adductomics–The next generation of adductomics towards assessing environmental health risks
This Discussion article aims to explore the potential for a new generation of assay to emerge
from cellular and urinary DNA adductomics which brings together DNA-RNA-and, to some …
from cellular and urinary DNA adductomics which brings together DNA-RNA-and, to some …
Screening DNA Damage in the Rat Kidney and Liver by Untargeted DNA Adductomics
N Ragi, SJ Walmsley, FC Jacobs… - Chemical research in …, 2024 - ACS Publications
Air pollution, tobacco smoke, and red meat are associated with renal cell cancer (RCC) risk
in the United States and Western Europe; however, the chemicals that form DNA adducts …
in the United States and Western Europe; however, the chemicals that form DNA adducts …
[HTML][HTML] DNA Adductomics: A Narrative Review of Its Development, Applications, and Future
M Cao, X Zhang - Biomolecules, 2024 - mdpi.com
DNA adductomics is the global study of all DNA adducts and was first proposed in 2006 by
the Matsuda group. Its development has been greatly credited to the advances in mass …
the Matsuda group. Its development has been greatly credited to the advances in mass …
Unlocking The Mysteries of DNA Adducts with Artificial Intelligence
Cellular genome is considered a dynamic blueprint of a cell since it encodes genetic
information that gets temporally altered due to various endogenous and exogenous insults …
information that gets temporally altered due to various endogenous and exogenous insults …