Dietary isothiocyanates inhibit cancer progression by modulation of epigenome

MK Sundaram, R Preetha, S Haque, N Akhter… - Seminars in Cancer …, 2022 - Elsevier
Cell cycle, growth, survival and metabolism are tightly regulated together and failure in
cellular regulation leads to carcinogenesis. Several signaling pathways like the PI3K, WNT …

[HTML][HTML] Natural bioactive compounds targeting histone deacetylases in human cancers: recent updates

A Bouyahya, N El Hachlafi, T Aanniz, I Bourais… - Molecules, 2022 - mdpi.com
Cancer is a complex pathology that causes a large number of deaths worldwide. Several
risk factors are involved in tumor transformation, including epigenetic factors. These factors …

[HTML][HTML] Application of Polyphenols and Flavonoids in Oncological Therapy

S Roszkowski - Molecules, 2023 - mdpi.com
The use of naturally derived drugs in anti-cancer therapies has grown exponentially in
recent years. Among natural compounds, polyphenols have shown potential therapeutic …

[HTML][HTML] Potential of Kalanchoe pinnata as a Cancer Treatment Adjuvant and an Epigenetic Regulator

ME Hernández-Caballero, JA Sierra-Ramírez… - Molecules, 2022 - mdpi.com
Cancer is a global public health problem that is related to different environmental and
lifestyle factors. Although the combination of screening, prevention, and treatment of cancer …

[HTML][HTML] Targeting of non-apoptotic cancer cell death mechanisms by quercetin: Implications in cancer therapy

H Yang, S Xu, L Tang, J Gong, H Fang… - Frontiers in …, 2022 - frontiersin.org
The ultimate goal of cancer treatment is to kill cancer cells, based on the use of various
therapeutic agents, such as chemotherapy, radiotherapy, or targeted therapy drugs. Most …

[HTML][HTML] DNA methylation and hydroxymethylation in cervical cancer: diagnosis, prognosis and treatment

H Zhu, H Zhu, M Tian, D Wang, J He, T Xu - Frontiers in Genetics, 2020 - frontiersin.org
Recent discoveries have led to the development of novel ideas and techniques that have
helped elucidate the correlation between epigenetics and tumor biology. Nowadays, the …

[HTML][HTML] Flavonoids as epigenetic modulators for prostate cancer prevention

S Izzo, V Naponelli, S Bettuzzi - Nutrients, 2020 - mdpi.com
Prostate cancer (PCa) is a multifactorial disease with an unclear etiology. Due to its high
prevalence, long latency, and slow progression, PCa is an ideal target for chemoprevention …

Polyphenols as adjunctive treatments in psychiatric and neurodegenerative disorders: Efficacy, mechanisms of action, and factors influencing inter-individual …

G Morris, E Gamage, N Travica, M Berk… - Free Radical Biology …, 2021 - Elsevier
The pathophysiology of psychiatric and neurodegenerative disorders is complex and
multifactorial. Polyphenols possess a range of potentially beneficial mechanisms of action …

[HTML][HTML] Metabolo-epigenetic interplay provides targeted nutritional interventions in chronic diseases and ageing

M Gómez de Cedrón, R Moreno Palomares… - Frontiers in …, 2023 - frontiersin.org
Epigenetic modifications are chemical modifications that affect gene expression without
altering DNA sequences. In particular, epigenetic chemical modifications can occur on …

Biocompatibility, cytotoxicity, antimicrobial and epigenetic effects of novel chitosan-based quercetin nanohydrogel in human cancer cells

S Abbaszadeh, M Rashidipour, P Khosravi… - International Journal …, 2020 - Taylor & Francis
Background Previous studies have reported that quercetin (Q) has a potential antibacterial
and anticancer activity. However, its application is limited by many important factors …