Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

The number of old people is rising worldwide, and advancing age is a major risk factor for
atherosclerotic cardiovascular disease. However, the mechanisms underlying this …

Haematopoietic ageing is marked by a loss of regenerative capacity and skewed
differentiation from haematopoietic stem cells (HSCs), leading to impaired blood production …

Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

The introduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the
human population represents a tremendous medical and economic crisis. Innate immunity …

In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult
life within the bone marrow, where they produce the mature cells necessary to maintain …

The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

The bone marrow contains peripheral nerves that promote haematopoietic regeneration
after irradiation or chemotherapy (myeloablation), but little is known about how this is …

Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research
interest, but the metabolic requirements of HSCs and their adaptations to their niches during …

Decline in hematopoietic stem cell (HSC) function with age underlies limited health span of
our blood and immune systems. In order to preserve health into older age, it is necessary to …