Reversing the Inflammatory Process—25 Years of Tumor Necrosis Factor-α Inhibitors

KN Muth, J Rech, FO Losch, A Hoerning - Journal of Clinical Medicine, 2023 - mdpi.com
Immune-mediated inflammatory diseases, such as rheumatoid arthritis, psoriatic arthritis,
peripheral and/or axial spondyloarthritis, Crohn's disease, and ulcerative colitis, are …

Drug-induced liver injury due to biologics and immune check point inhibitors

F Bessone, ES Björnsson - Medical Clinics, 2023 - medical.theclinics.com
Biological agents have in the last two decades become very important therapeutic agents,
particularly for the treatment of various autoimmune disorders. The most widely used …

Immuno-inflammatory in vitro hepatotoxicity models to assess side effects of biologicals exemplified by aldesleukin

LA Roser, S Luckhardt, N Ziegler, D Thomas… - Frontiers in …, 2023 - frontiersin.org
Introduction Hepatotoxicity induced by immunotherapeutics is an appearing cause for
immune-mediated drug-induced liver injury. Such immuno-toxic mechanisms are difficult to …

Global lake health in the Anthropocene: Societal implications and treatment strategies

GA Weyhenmeyer, AV Chukwuka, O Anneville… - Earth's …, 2024 - Wiley Online Library
Abstract The world's 1.4 million lakes (≥ 10 ha) provide many ecosystem services that are
essential for human well‐being; however, only if their health status is good. Here, we …

Beyond the hype and toward application: liver complex in vitro models in preclinical drug safety

S Jadalannagari, L Ewart - Expert Opinion on Drug Metabolism & …, 2024 - Taylor & Francis
ABSTRACT Introduction Drug induced Liver-Injury (DILI) is a leading cause of drug attrition
and complex in vitro models (CIVMs), including three dimensional (3D) spheroids, 3D bio …

[HTML][HTML] Overview of the immunological mechanisms in hepatitis B virus reactivation: Implications for disease progression and management strategies

H Ma, QZ Yan, JR Ma, DF Li… - World Journal of …, 2024 - ncbi.nlm.nih.gov
Hepatitis B virus (HBV) reactivation is a clinically significant challenge in disease
management. This review explores the immunological mechanisms underlying HBV …

[HTML][HTML] Checkpoint inhibitor-induced hepatotoxicity: Role of liver biopsy and management approach

F Bessone, ES Bjornsson - World Journal of Hepatology, 2022 - ncbi.nlm.nih.gov
Immunological checkpoint inhibitors (ICIs) have revolutionized therapy of many different
malignanices. Concomitant immune-mediated adverse effects are common and can affect …

[图书][B] Hepatology: An Update, An Issue of Medical Clinics of North America, E-Book: Hepatology: An Update, An Issue of Medical Clinics of North America, E-Book

AV Kulkarni, KR Reddy - 2023 - books.google.com
In this issue of Medical Clinics of North America, guest editors Drs. Anand V. Kulkarni and K.
Rajender Reddy bring their considerable expertise to the topic of Hepatology: An Update …

Emerging role of immunotherapy for cancer as a major cause of drug-induced liver injury

N Hernandez, F Bessone… - Annals of …, 2024 - pubmed.ncbi.nlm.nih.gov
Emerging role of immunotherapy for cancer as a major cause of drug-induced liver injury
Emerging role of immunotherapy for cancer as a major cause of drug-induced liver injury Ann …