Exposure to arsenic in contaminated drinking water is an emerging public health problem
that impacts more than 200 million people worldwide. Accumulating lines of evidence from …

14-3-3 Proteins are a ubiquitous family of molecules that participate in protein kinase
signaling pathways within all eukaryotic cells. Functioning as phosphoserine …

An emerging concept in the field of cancer biology is that a rare population of 'tumour stem
cells' exists among the heterogeneous group of cells that constitute a tumour. This concept …

A profound cytotoxic action of the antimalarial, artesunate (ART), was identified against 55
cancer cell lines of the US National Cancer Institute (NCI). The 50% inhibition …

Background The discovery of novel phytochemicals represents a reasonable approach to
fight malignancies, especially those which are resistant to standard chemotherapy. Purpose …

Targeting tumour suppressor gene pathways is an attractive therapeutic strategy in cancer.
Since the first clinical trial took place in 1996, at least 20 other trials have investigated the …

Until recently, the ability of ARF (human p14 ARF, murine p19 ARF) tumour-suppressor
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …

Nasopharyngeal carcinoma (NPC) is a common disease in Hong Kong and southern
provinces of China. EBV infection is believed to play a critical role in the development of …

Knowledge of the roles of proteins that are abnormally suppressed or activated due to
mutation in the DNA sequences of the common tumor suppressor genes, p14ARF and p53 …

The p53 tumor suppressor protein is a key transcription factor that regulates several
signaling pathways involved in the cell's response to stress. Through stress‐induced …